Title:
NUCLEIC ACID COMPLEX
Document Type and Number:
WIPO Patent Application WO/2017/131236
Kind Code:
A1
Abstract:
The present invention relates to the nucleic acid complex expressed by formula 1. Formula 1: (In formula 1, X is an oligonucleotide, L1 and L2 each independently represents a sugar ligand, and S1, S2 and S3 each independently represents a linker.)
Inventors:
UEHARA KEIJI (JP)
SUZUKI YASUHIRO (JP)
IWAI HIROTO (JP)
HOMMA MASAKAZU (JP)
FUKUDA YUICHI (JP)
KIUCHI TATSUTO (JP)
SUZUKI YASUHIRO (JP)
IWAI HIROTO (JP)
HOMMA MASAKAZU (JP)
FUKUDA YUICHI (JP)
KIUCHI TATSUTO (JP)
Application Number:
PCT/JP2017/003249
Publication Date:
August 03, 2017
Filing Date:
January 30, 2017
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
A61K31/7088; C12N15/113; A61K31/713; A61P43/00; C07C237/10; C07C247/04; C07C271/16; C07H15/04
Domestic Patent References:
| WO2014179629A2 | 2014-11-06 | |||
| WO2014179627A2 | 2014-11-06 | |||
| WO2009073809A2 | 2009-06-11 | |||
| WO2013075035A1 | 2013-05-23 | |||
| WO2015105083A1 | 2015-07-16 | |||
| WO2014179620A1 | 2014-11-06 | |||
| WO2005113571A2 | 2005-12-01 | |||
| WO2013173601A1 | 2013-11-21 | |||
| WO2013173637A1 | 2013-11-21 | |||
| WO2015006740A2 | 2015-01-15 |
Foreign References:
| JP2014504295A | 2014-02-20 | |||
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Other References:
NAIR JAYAPRAKASH K. ET AL.: "Multivalent N- Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958 - 16961, XP055181463
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958 - 16961
TETRAHEDRON LETTERS, vol. 38, 1997, pages 8735
TETRAHEDRON, vol. 54, 1998, pages 3607
NUCLEIC ACID RESEARCH, vol. 32, 2004, pages e175
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 75, 2010, pages 1569
CHEM BIO CHEM, vol. 13, 2012, pages 2513
CHEM. COMMUN., vol. 51, 2015, pages 9737
ACC. CHEM. RES., vol. 32, 1999, pages 624
J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
NUCLEIC ACID RESEARCH, vol. 35, 2007, pages 3287
NUCLEIC ACID RESEARCH, vol. 41, 2013, pages 10086
HEPATOLOGY, vol. 59, 2014, pages 216
NUCLEIC ACIDS RESEARCH, vol. 32, 1998, pages 936
NUCLEIC ACIDS RESEARCH, vol. 30, 1993, pages 2435
"Bioorganic Medicinal Chemistry", vol. 17, 2009, pages: 7254
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 1978
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
"The Fourth Series of Experimental Chemistry", vol. 19, 1992, MARUZEN CO., LTD., article "Synthesis of Organic Compound I"
"The Fourth Series of Experimental Chemistry", vol. 20, 1992, MARUZEN CO., LTD., article "Synthesis of Organic Compound II"
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958
NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 3287
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, pages 383 - 386
T.W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
"The Fourth Series of Experimental Chemistry, Organic Synthesis", 1992, MARUZEN CO., LTD., pages: 258
"March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure"
BIOCONJUGATE CHEMISTRY, vol. 21, 2010, pages 187 - 202
"Current Protocols in Nucleic Acid Chemistry", September 2010
BIOCONJUGATE CHEMISTRY, vol. 26, 2015, pages 1451 - 1455
"Bioconjugate Chemistry", vol. 26, 2015, pages: 1451 - 1455
"Bioconjugate Chemistry", vol. 22, 2011, pages: 1723 - 1728
"Bioconjugate Chemistry", vol. 22, 2011, pages: 690 - 699
MOLECULES, vol. 17, 2012, pages 13825 - 13843
ACS NANO, vol. 9, 2015, pages 9652 - 9664
BIOCONJUGATE CHEMISTRY, vol. 14, 2003, pages 232 - 238
JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 2016, pages 2718 - 2733
JOURNAL OF ORGANIC CHEMISTRY, vol. 74, 2009, pages 6837 - 6842
ORGANIC LETTER, vol. 16, 2014, pages 6318 - 6321
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 2433 - 2446
BIOCONJUGATE CHEMISTRY, vol. 22, 2011, pages 1723 - 1728
See also references of EP 3409780A4
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958 - 16961
TETRAHEDRON LETTERS, vol. 38, 1997, pages 8735
TETRAHEDRON, vol. 54, 1998, pages 3607
NUCLEIC ACID RESEARCH, vol. 32, 2004, pages e175
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 75, 2010, pages 1569
CHEM BIO CHEM, vol. 13, 2012, pages 2513
CHEM. COMMUN., vol. 51, 2015, pages 9737
ACC. CHEM. RES., vol. 32, 1999, pages 624
J. AM. CHEM. SOC., vol. 123, 2001, pages 4653
J. AM. CHEM. SOC., vol. 122, 2000, pages 6900
NUCLEIC ACID RESEARCH, vol. 35, 2007, pages 3287
NUCLEIC ACID RESEARCH, vol. 41, 2013, pages 10086
HEPATOLOGY, vol. 59, 2014, pages 216
NUCLEIC ACIDS RESEARCH, vol. 32, 1998, pages 936
NUCLEIC ACIDS RESEARCH, vol. 30, 1993, pages 2435
"Bioorganic Medicinal Chemistry", vol. 17, 2009, pages: 7254
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 1978
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
"The Fourth Series of Experimental Chemistry", vol. 19, 1992, MARUZEN CO., LTD., article "Synthesis of Organic Compound I"
"The Fourth Series of Experimental Chemistry", vol. 20, 1992, MARUZEN CO., LTD., article "Synthesis of Organic Compound II"
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 136, 2014, pages 16958
NUCLEIC ACIDS RESEARCH, vol. 35, 2007, pages 3287
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, pages 383 - 386
T.W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
"The Fourth Series of Experimental Chemistry, Organic Synthesis", 1992, MARUZEN CO., LTD., pages: 258
"March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure"
BIOCONJUGATE CHEMISTRY, vol. 21, 2010, pages 187 - 202
"Current Protocols in Nucleic Acid Chemistry", September 2010
BIOCONJUGATE CHEMISTRY, vol. 26, 2015, pages 1451 - 1455
"Bioconjugate Chemistry", vol. 26, 2015, pages: 1451 - 1455
"Bioconjugate Chemistry", vol. 22, 2011, pages: 1723 - 1728
"Bioconjugate Chemistry", vol. 22, 2011, pages: 690 - 699
MOLECULES, vol. 17, 2012, pages 13825 - 13843
ACS NANO, vol. 9, 2015, pages 9652 - 9664
BIOCONJUGATE CHEMISTRY, vol. 14, 2003, pages 232 - 238
JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 2016, pages 2718 - 2733
JOURNAL OF ORGANIC CHEMISTRY, vol. 74, 2009, pages 6837 - 6842
ORGANIC LETTER, vol. 16, 2014, pages 6318 - 6321
JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, 2011, pages 2433 - 2446
BIOCONJUGATE CHEMISTRY, vol. 22, 2011, pages 1723 - 1728
See also references of EP 3409780A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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