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Title:
NUCLEIC ACID COMPLEX
Document Type and Number:
WIPO Patent Application WO/2020/111280
Kind Code:
A1
Abstract:
The present invention provides a nucleic acid complex represented by formula 1. Formula 1: (In formula 1, X is a double-stranded nucleic acid that comprises a sense strand and an antisense strand and that includes a duplex region of at least 11 base pairs; the double-stranded nucleic acid is complementary with any of the target APCS mRNA sequences listed in Tables 1-1 to 1-13 in an oligonucleotide strand having a strand length of 17-30 nucleotides in the antisense strand, and the 3' end or 5' end of the sense strand bonds to S3; L1 and L2 each independently represent a sugar ligand; S1, S2, and S3 each independently represent a linker.)

Inventors:
IWAI HIROTO (JP)
IMAEDA TAKASHI (JP)
ARIYAMA HIROYUKI (JP)
MURAKAMI TAKUYA (JP)
Application Number:
PCT/JP2019/047044
Publication Date:
June 04, 2020
Filing Date:
December 02, 2019
Export Citation:
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Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K31/7105; A61K31/713; A61K47/54; A61K48/00; A61P25/28; C07H15/04; C12N15/113
Domestic Patent References:
WO2017131236A12017-08-03
WO2018221649A12018-12-06
WO2019027009A12019-02-07
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Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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