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Title:
NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE
Document Type and Number:
WIPO Patent Application WO/2020/233680
Kind Code:
A1
Abstract:
An siRNA which inhibits kininogen (KNG) gene expression, a pharmaceutical composition containing the siRNA, and an siRNA conjugate. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The siRNA contains a sense strand and an antisense strand. The sense strand contains nucleotide sequence I, nucleotide sequence I having the same length as the nucleotide sequence shown in SEQ ID NO: 1, with no more than three nucleotide differences. The antisense strand contains nucleotide sequence II, nucleotide sequence II having the same length as the nucleotide sequence shown in SEQ ID NO: 2, with no more than three nucleotide differences. The siRNA, the pharmaceutical composition thereof and the siRNA conjugate can effectively treat and/or prevent septicemia.

Inventors:
ZHANG HONGYAN (CN)
GAO SHAN (CN)
KANG DAIWU (CN)
Application Number:
PCT/CN2020/091614
Publication Date:
November 26, 2020
Filing Date:
May 21, 2020
Export Citation:
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Assignee:
SUZHOU RIBO LIFE SCIENCE CO LTD (CN)
International Classes:
C12N15/113; A61K31/713; C07H15/04
Domestic Patent References:
WO2015006740A22015-01-15
Foreign References:
CN108271386A2018-07-10
CN103380113A2013-10-30
CN108220293A2018-06-29
CN108064294A2018-05-22
CN110959011A2020-04-03
Other References:
SENNBLAD, B. ET AL.: "Homo Sapiens Kininogen 1 (KNG1), Transcript Variant 1, mRNA", GENBANK, 2 May 2018 (2018-05-02), DOI: 20200803145443Y
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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