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Title:
NUCLEIC ACID THAT INHIBITS EXPRESSION OF MEX3B GENE, MEX3B GENE EXPRESSION INHIBITING AGENT, METHOD FOR INHIBITING MEX3B GENE EXPRESSION, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR DISEASE CAUSED BY MEX3B GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2021/065686
Kind Code:
A1
Abstract:
Provided are a nucleic acid with improved ability to inhibit the expression of the MEX3B gene with low occurrence of cytotoxicity side effects, an MEX3B gene expression inhibiting agent that includes the nucleic acid, a method for inhibiting MEX3B gene expression, and a prophylactic or therapeutic drug for a disease caused by MEX3B gene expression. The present invention is a nucleic acid that is any of (1) to (3): (1) an oligonucleotide that comprises the base sequence represented by SEQ ID NO: 1 or 2 in the sequence listing; (2) an antisense oligonucleotide that inhibits expression of the MEX3B gene and that comprises a base sequence derived by deletion, substitution, and/or addition of one or two bases in the base sequence represented by SEQ ID NO: 1 or 2 in the sequence listing; and (3) an antisense oligonucleotide that inhibits expression of the MEX3B gene and that includes the base sequence represented by SEQ ID NO: 3 in the sequence listing.

Inventors:
AKIYAMA TETSU (JP)
YAMAZUMI YUSUKE (JP)
Application Number:
PCT/JP2020/036105
Publication Date:
April 08, 2021
Filing Date:
September 24, 2020
Export Citation:
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Assignee:
UNIV TOKYO (JP)
International Classes:
A61K48/00; A61K31/7088; A61P1/04; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P11/14; A61P13/12; A61P17/00; A61P19/02; A61P25/18; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C12N15/113
Domestic Patent References:
WO2018008749A12018-01-11
WO2018008750A12018-01-11
Foreign References:
JP2018011593A2018-01-25
JP2017212911A2017-12-07
Other References:
YAMAZUMI, YUSUKE ET AL.: "The RNA-binding protein Mex-3B plays critical roles in the development of steroid -resistant neutrophilic airway inflammation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 519, 4 September 2019 (2019-09-04), pages 220 - 226, XP085840267, DOI: 10.1016/j.bbrc.2019.08.158
YAMAZUMI, YUSUKE ET AL.: "The RNA Binding Protein Mex-3B Is Required for IL -33 Induction in the Development of Allergic Airway Inflammation", CELL REPORTS, vol. 16, 2016, pages 2456 - 2471, XP055450972, DOI: 10.1016/j.celrep.2016.07.062
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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