Title:
NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, POLYNUCLEOTIDE PRODUCTION METHOD, POLYNUCLEOTIDE, AND BINDING NUCLEIC ACID MOLECULE PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/096831
Kind Code:
A1
Abstract:
Provided are a novel nucleoside derivative or salt thereof, polynucleotide synthesis reagent, polynucleotide production method, polynucleotide, and binding nucleic acid molecule production method. This nucleoside derivative or salt thereof is characterized in being represented by chemical formula (1). In chemical formula (1): Su is an atom group with a sugar backbone in the nucleoside residue or an atom group with a sugar phosphate backbone in the nucleotide residue, and may or may not have a protecting group; each of L1 and L2 independently is a straight or branched saturated or unsaturated C2-10 hydrocarbon group; X1 is an imino group (-NR1-), ether group (-O-) or thioether group (-S-); and R1 is a hydrogen atom or straight or branched saturated or unsaturated C2-10 hydrocarbon group.
Inventors:
MINAGAWA HIROTAKA (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
Application Number:
PCT/JP2017/037093
Publication Date:
May 31, 2018
Filing Date:
October 12, 2017
Export Citation:
Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C07H19/073; C12N15/09; C12N15/11
Domestic Patent References:
| WO2015064223A1 | 2015-05-07 |
Foreign References:
| JP2016056136A | 2016-04-21 | |||
| JP2013040118A | 2013-02-28 | |||
| JP2012200204A | 2012-10-22 | |||
| JP2016230196A |
Other References:
IMAIZUMI, Y. ET AL.: "Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 25, 26 June 2013 (2013-06-26), pages 9412 - 9419, XP055422191, DOI: 10.1021/ja4012222
MASAYASU KUWAHARA: "Kobunshi no re-programming Hi-tennen Bunshi o Donyu shita Kakusan aptamer no Sosei (Creation of nucleic acid aptamers that contain unnatural nucleotides)", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009512934
See also references of EP 3546471A4
MASAYASU KUWAHARA: "Kobunshi no re-programming Hi-tennen Bunshi o Donyu shita Kakusan aptamer no Sosei (Creation of nucleic acid aptamers that contain unnatural nucleotides)", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009512934
See also references of EP 3546471A4
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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