Title:
NUCLEOSIDE DERIVATIVE OR SALT THEREOF, REAGENT FOR SYNTHESIZING POLYNUCLEOTIDE, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE
Document Type and Number:
WIPO Patent Application WO/2018/052063
Kind Code:
A1
Abstract:
Provided are a novel nucleoside derivative or a salt thereof, a reagent for synthesizing a polynucleotide, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. This nucleoside derivative or a salt thereof is characterized by being represented by chemical formula (1). [Chem. 1] In chemical formula (1), Su represents an atomic group having a sugar backbone in the nucleoside residue or an atomic group having a sugar phosphate backbone in the nucleotide residue, which may or may not have a protecting group, L1 and L2 each independently represent a linear or branched saturated or unsaturated hydrocarbon group having 2-10 carbon atoms, X1 and X2 each independently represent an imino group (-NR1-), an ether group (-O-), or a thioether group (-S-), and R1 represents a hydrogen atom or a linear or branched saturated or unsaturated hydrocarbon group having 2-10 carbon atoms.
Inventors:
MINAGAWA HIROTAKA (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
Application Number:
PCT/JP2017/033210
Publication Date:
March 22, 2018
Filing Date:
September 14, 2017
Export Citation:
Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C07H19/073; C07H19/10; C07K16/00; C12N9/26; C12N15/115
Foreign References:
| JP2016056136A | 2016-04-21 | |||
| JP2013040118A | 2013-02-28 | |||
| JP2012200204A | 2012-10-22 | |||
| JP2016180893A | 2016-09-15 | |||
| JP2017020064W | 2017-05-30 |
Other References:
IMAIZUMI,Y. ET AL.: "Efficacy of Base- Modification on Target Binding of Small Molecule DNA Aptamers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 25, 2013, pages 9412 - 9419, XP055422191, DOI: doi:10.1021/ja4012222
MASAYASU KUWAHARA: "Kobunshi no Re-Programming Hitennen Bunshi o Donyu shita Kakusan Aptamer no Sosei", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009512934, ISSN: 0454-1138
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
MASAYASU KUWAHARA: "Kobunshi no Re-Programming Hitennen Bunshi o Donyu shita Kakusan Aptamer no Sosei", KOBUNSHI, vol. 63, no. 10, 2014, pages 730 - 731, XP009512934, ISSN: 0454-1138
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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