Title:
NUCLEOSIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/085509
Kind Code:
A1
Abstract:
A nucleoside derivative represented by formula (1) or a salt thereof. In the formula, R1 represents an alkoxy group, a hydrogen atom or a halogen atom; R2 and R4 may be the same as or different from each other and independently represent a hydrogen atom, a protecting group for a hydroxyl group, a phosphoric acid group, a protected phosphoric acid group, or -P(=O)nR5R6 (wherein n represents 0 or 1, and R5 and R6 may be the same as or different from each other and independently represent any one group selected from a hydrogen atom, a hydroxyl group, a protected hydroxyl group, a mercapto group, a protected mercapto group, an alkoxy group, a cyanoalkoxy group, an amino group and a substituted amino group, provided that, when n represents 1, the case where each of R5 and R6 represents a hydrogen atom is excluded); R3 represents -(CH2)mNHR7 (wherein m represents an integer of 1 to 6, and R7 represents a hydrogen atom, an alkyl group, an alkenyl group, or a protecting group for an amino group); and B represents a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group, a substituted purin-9-yl group or a substituted 2-oxo-pyrimidin-1-yl group.
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Inventors:
UENO YOSHIHITO (JP)
Application Number:
PCT/JP2020/040526
Publication Date:
May 06, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
YAMASA CORP (JP)
YAMASA CORP (JP)
International Classes:
A61K48/00; A61K31/713; C07H19/10; C12N15/113
Domestic Patent References:
| WO2018110678A1 | 2018-06-21 | |||
| WO2018110678A1 | 2018-06-21 | |||
| WO2018011678A1 | 2018-01-18 |
Foreign References:
| CN110204583A | 2019-09-06 | |||
| JP2002521310A | 2002-07-16 | |||
| US5446137A | 1995-08-29 |
Other References:
HELVATICA CHIMICA ACTA, vol. 83, 2000, pages 128 - 151
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, 2012, pages 3233 - 3245
BIOORGANIC & CHEMISTRY LETTERS, 1999, pages 2667 - 2672
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 78, 2013, pages 9956 - 9962
J. PHARM. SCI., 1977, pages 1 - 19
BIOORGANIC & MEDICAL CHEMISTRY, vol. 11, 2003, pages 211 - 2226
"The Journal of Organic Chemistry", vol. 78, 2013, pages: 9956 - 9962
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, 2012, pages 3233 - 3245
BIOORGANIC & CHEMISTRY LETTERS, 1999, pages 2667 - 2672
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 78, 2013, pages 9956 - 9962
J. PHARM. SCI., 1977, pages 1 - 19
BIOORGANIC & MEDICAL CHEMISTRY, vol. 11, 2003, pages 211 - 2226
"The Journal of Organic Chemistry", vol. 78, 2013, pages: 9956 - 9962
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL (JP)
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