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Title:
NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
Document Type and Number:
WIPO Patent Application WO2004007512
Kind Code:
A3
Abstract:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Inventors:
BHAT BALKRISHEN (US)
CARROLL STEVEN S (US)
ELDRUP ANNE B (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
PRAKASH THAZHA P (US)
Application Number:
PCT/US2003/021589
Publication Date:
April 08, 2004
Filing Date:
July 11, 2003
Export Citation:
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Assignee:
MERCK & CO INC (US)
ISIS PHARMACEUTICALS INC (US)
BHAT BALKRISHEN (US)
CARROLL STEVEN S (US)
ELDRUP ANNE B (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
PRAKASH THAZHA P (US)
International Classes:
C12N9/99; A61K31/7056; A61K31/7064; A61K38/21; A61K45/00; A61P1/16; A61P31/14; A61P43/00; C07H19/14; (IPC1-7): C07H19/14; A61K31/70
Foreign References:
Other References:
DATABASE CAPLUS [online] IIMORI ET AL.: "A study on conformationally restricted sangivamycins and their inhibitory abilities of protein kinases", XP002973118, accession no. STN Database accession no. 1993:160564
MURAI ET AL.: "A synthesis and an X-ray analysis of 2'-C, 3'-C- and 5'-C-methylsangivamycins", HETEROCYCLES, vol. 33, no. 1, 1992, pages 391 - 404, XP002973119
IIMORI ET AL.: "2'-C, 3'-C- and 5'-C-methylsangivamycins: conformational lock with the methyl group", TETRAHEDRON LETTERS, vol. 32, no. 49, 1991, pages 7273 - 7276, XP002961627
See also references of EP 1556399A4
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