Title:
NUCLEOTIDES FOR THE TREATMENT OF LIVER CANCER
Document Type and Number:
WIPO Patent Application WO/2015/081133
Kind Code:
A3
Abstract:
Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z1, Z2, Z3, Z4, V, W, X, Ar, R1 and R2 are as described herein.
Inventors:
DOUSSON CYRIL B (FR)
DUKHAN DAVID (FR)
PARSY CHRISTOPHE CLAUDE (FR)
DUKHAN DAVID (FR)
PARSY CHRISTOPHE CLAUDE (FR)
Application Number:
PCT/US2014/067485
Publication Date:
December 17, 2015
Filing Date:
November 25, 2014
Export Citation:
Assignee:
IDENIX PHARMACEUTICALS INC (US)
International Classes:
C07H19/06; A61K31/7068; A61K31/7076; A61K31/708; A61P35/00; C07H19/10; C07H19/16; C07H19/20
Domestic Patent References:
| WO2005012327A2 | 2005-02-10 | |||
| WO2006100439A1 | 2006-09-28 | |||
| WO2009052050A1 | 2009-04-23 | |||
| WO2012040127A1 | 2012-03-29 | |||
| WO2014148949A1 | 2014-09-25 | |||
| WO2014076490A1 | 2014-05-22 | |||
| WO2015056213A1 | 2015-04-23 | |||
| WO2015034420A1 | 2015-03-12 | |||
| WO2015134334A1 | 2015-09-11 | |||
| WO2012088155A1 | 2012-06-28 |
Foreign References:
| US20120070411A1 | 2012-03-22 | |||
| US20040077588A1 | 2004-04-22 | |||
| US20100227834A1 | 2010-09-09 | |||
| CN104119385A | 2014-10-29 |
Other References:
MAURIZIO QUINTILIANI ET AL: "Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 14, 1 July 2011 (2011-07-01), pages 4338 - 4345, XP055016528, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2011.05.037
KRISTJAN S. GUDMUNDSSON ET AL: "Phosphoramidate Protides of 2',3'-Dideoxy-3'-fluoroadenosine and Related Nucleosides with Potent Activity Against HIV and HBV", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 22, no. 10, 1 October 2003 (2003-10-01), pages 1953 - 1961, XP055211263, ISSN: 1525-7770, DOI: 10.1081/NCN-120025242
MCGUIGAN C ET AL: "Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 13, no. 9, 2 May 2005 (2005-05-02), pages 3219 - 3227, XP027637541, ISSN: 0968-0896, [retrieved on 20050502]
MARCO DERUDAS ET AL: "Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1 January 2010 (2010-01-01), England, pages 15 - 31, XP055221244, Retrieved from the Internet [retrieved on 20151015], DOI: 10.3851/IMP1661
MAGDALENA SLUSARCZYK ET AL: "Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 4, 27 February 2014 (2014-02-27), pages 1531 - 1542, XP055205033, ISSN: 0022-2623, DOI: 10.1021/jm401853a
KRISTJAN S. GUDMUNDSSON ET AL: "Phosphoramidate Protides of 2',3'-Dideoxy-3'-fluoroadenosine and Related Nucleosides with Potent Activity Against HIV and HBV", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 22, no. 10, 1 October 2003 (2003-10-01), pages 1953 - 1961, XP055211263, ISSN: 1525-7770, DOI: 10.1081/NCN-120025242
MCGUIGAN C ET AL: "Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 13, no. 9, 2 May 2005 (2005-05-02), pages 3219 - 3227, XP027637541, ISSN: 0968-0896, [retrieved on 20050502]
MARCO DERUDAS ET AL: "Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1 January 2010 (2010-01-01), England, pages 15 - 31, XP055221244, Retrieved from the Internet
MAGDALENA SLUSARCZYK ET AL: "Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 4, 27 February 2014 (2014-02-27), pages 1531 - 1542, XP055205033, ISSN: 0022-2623, DOI: 10.1021/jm401853a
Attorney, Agent or Firm:
PATHAK, Rahul et al. (275 Battery Street Suite 260, San Francisco California, US)
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