Title:
O-HYDROXYBENZOIC ACID POLYGLYCOL ESTER COMPOUND, AND SYNTHETIC PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/073038
Kind Code:
A1
Abstract:
Disclosed in present invention are an o-hydroxybenzoic acid polyglycol ester compound, and a synthetic preparation method and pharmaceutical use thereof. The o-hydroxybenzoic acid polyglycol ester compound has a structure shown as formula I or formula II. The compound has a remarkable effect of prolonging the blood coagulation time, is suitable for prevention and treatment of thrombotic diseases, and also has the advantages of good safety, simple and convenient medication, low costs and easily available raw materials, and convenient transportation and preservation; in formula I or formula II, n=1-20, and R is selected from H, -C1-20 alkyl, and 2-acetoxybenzoyl.
Inventors:
NIE DAN (CN)
Application Number:
PCT/CN2020/080340
Publication Date:
April 22, 2021
Filing Date:
March 20, 2020
Export Citation:
Assignee:
XINXIANG HAIYING BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C69/76; C07C7/14; A61K31/235; A61P7/02
Domestic Patent References:
| WO1996015809A2 | 1996-05-30 |
Foreign References:
| CN110668947A | 2020-01-10 | |||
| CN1616404A | 2005-05-18 | |||
| CN1616404A | 2005-05-18 | |||
| EP0576868A1 | 1994-01-05 |
Other References:
FOLEY DAVID W., RAVINDRA B. PATHAK, THERESA R. PHILIIPS, GAYLE L. WILSON, PATRICK D. BAILEY, MYRTANI PIERI, ANISH SENAN, DAVID MER: "Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 156, 30 June 2018 (2018-06-30), pages 180 - 189, XP055802177, DOI: 10.1016/j.ejmech.2018.06.064
Attorney, Agent or Firm:
BEIJING HUAKE UNION PATENT OFFICE(GENERAL PARTNERSHIP) (CN)
Download PDF: