Title:
OBLIGATE ANAEROBIC HUMAN INTESTINAL MICROBE FOR CANCER TREATMENT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/060945
Kind Code:
A1
Abstract:
The present invention pertains to a novel Akkermansia sp. strain and a use thereof. A novel Akkermansia sp. HB03 strain provided in the present invention lacks toxic genes and thus does not cause side effects in vivo, and also exhibits excellent anti-cancer activity and can thus be widely used in the development of agents for preventing or treating cancer.
Inventors:
SONG JINHOI (KR)
YOON JUN BEOM (KR)
SON MI JIN (KR)
SONG DA YOUNG (KR)
YOON JUN BEOM (KR)
SON MI JIN (KR)
SONG DA YOUNG (KR)
Application Number:
PCT/KR2020/013159
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
HEALTHBIOME (KR)
International Classes:
C12N1/20; A23L33/135; A61K35/74; A61K45/06; A61P3/00; A61P25/00; A61P31/04; A61P35/00; C12N1/36; C12R1/01
Foreign References:
| KR20130021920A | 2013-03-06 | |||
| US20180296613A1 | 2018-10-18 | |||
| KR20150093711A | 2015-08-18 | |||
| US20170368108A1 | 2017-12-28 |
Other References:
TING ZHANG ,QIANQIAN LI ,LEI CHENG ,HEENA BUCH,FAMING ZHANG: "Akkermansia muciniphila is a promising probiotic", MICROBIAL BIOTECHNOLOGY, vol. 12, no. 6, 21 April 2019 (2019-04-21), pages 1109 - 1125, XP055795705, DOI: 10.1111/1751-7915.13410
YUJI NAITO ET AL.: "A next-generation beneficial microbe: Akkermansia muciniphila", J CLIN BIOCHEM NUTR., vol. 63, no. 1, July 2018 (2018-07-01), pages 33 - 35, XP055804715, DOI: 10.3164/jcbn.18-57
MATTHEW R OLM ET AL.: "dRep: a tool for fast and accurate genome comparisons that enables improved genome recovery from metagenomes through de-replication", ISME J., vol. 11, no. 12, December 2017 (2017-12-01), pages 2864 - 2868
SEEMANN T. PROKKA: "rapid prokaryotic genome annotation", BIOINFORMATICS, vol. 30, no. 14, 15 July 2014 (2014-07-15), pages 2068 - 9
PRICE MNDEHAL PSARKIN AP: "FastTree 2--approximately maximum-likelihood trees for large alignments", PLOS ONE, vol. 5, no. 3, 10 March 2010 (2010-03-10), pages e9490
PROKKA: "Seemann T. Prokka: rapid prokaryotic genome annotation.", BIOINFORMATICS, vol. 30, no. 14, 15 July 2014 (2014-07-15), pages 2068 - 2069
PRICE MN, DEHAL PS, ARKIN AP: "FastTree 2--approximately maximum-likelihood trees for large alignments.", PLOS ONE, vol. 5, no. 3, 10 March 2010 (2010-03-10), pages e9490
NAT. MED., vol. 23, 2017, pages 107 - 113
YUJI NAITO ET AL.: "A next-generation beneficial microbe: Akkermansia muciniphila", J CLIN BIOCHEM NUTR., vol. 63, no. 1, July 2018 (2018-07-01), pages 33 - 35, XP055804715, DOI: 10.3164/jcbn.18-57
MATTHEW R OLM ET AL.: "dRep: a tool for fast and accurate genome comparisons that enables improved genome recovery from metagenomes through de-replication", ISME J., vol. 11, no. 12, December 2017 (2017-12-01), pages 2864 - 2868
SEEMANN T. PROKKA: "rapid prokaryotic genome annotation", BIOINFORMATICS, vol. 30, no. 14, 15 July 2014 (2014-07-15), pages 2068 - 9
PRICE MNDEHAL PSARKIN AP: "FastTree 2--approximately maximum-likelihood trees for large alignments", PLOS ONE, vol. 5, no. 3, 10 March 2010 (2010-03-10), pages e9490
PROKKA: "Seemann T. Prokka: rapid prokaryotic genome annotation.", BIOINFORMATICS, vol. 30, no. 14, 15 July 2014 (2014-07-15), pages 2068 - 2069
PRICE MN, DEHAL PS, ARKIN AP: "FastTree 2--approximately maximum-likelihood trees for large alignments.", PLOS ONE, vol. 5, no. 3, 10 March 2010 (2010-03-10), pages e9490
NAT. MED., vol. 23, 2017, pages 107 - 113
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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