Title:
OLIGOMERIC COMPOUNDS HAVING MODIFIED PHOSPHATE GROUPS
Document Type and Number:
WIPO Patent Application WO2003087115
Kind Code:
A3
Abstract:
Oligomeric compounds having at least one phosphorothioate monoester are provided having increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
Inventors:
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
Application Number:
PCT/US2003/010840
Publication Date:
November 04, 2004
Filing Date:
April 09, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
International Classes:
C07H21/00; C12N5/02; C12N15/113; A61K38/00; (IPC1-7): A61K48/00; C07H21/04
Other References:
TSURUOKA H. ET AL: "Synthesis and Conformational Properties of Oligonucleotides Incorporating 2'-O-Phosphorylated Ribonucleotides as Structural Motifs of Pre-tRNA Splicing Intermediates", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 22, 2000, pages 7479 - 7494, XP002980499
LORSCH J.R. ET AL: "Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template", NUCLEIC ACIDS RESEARCH, vol. 23, no. 15, 1995, pages 2811 - 2814, XP002980500
See also references of EP 1496943A4
LORSCH J.R. ET AL: "Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template", NUCLEIC ACIDS RESEARCH, vol. 23, no. 15, 1995, pages 2811 - 2814, XP002980500
See also references of EP 1496943A4
Download PDF:
Previous Patent: CHIRAL INTERMEDIATE AND PROCESS FOR THE PRODUCTION THEREOF
Next Patent: METHOD FOR PRODUCING BETA-L-2'DEOXY-THYMIDINE
Next Patent: METHOD FOR PRODUCING BETA-L-2'DEOXY-THYMIDINE