Title:
OLIGONUCLEOTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2021/032777
Kind Code:
A8
Abstract:
The disclosure relates to GalNAc moieties comprising at least one GalNAc monomer. The disclosure also relates to GalNAc-oligonucleotide conjugates comprising GalNAc moieties and oligonucleotides, e.g., saRNAs or siRNAs useful in regulating the expression of a target gene. Methods of using the GalNAc- oligonucleotide conjugates are also provided.
Inventors:
DEBACKER ALEXANDRE (GB)
VOUTILA JON (GB)
MITCHELL LEE (GB)
MCKEEN CATHERINE M (GB)
VOUTILA JON (GB)
MITCHELL LEE (GB)
MCKEEN CATHERINE M (GB)
Application Number:
PCT/EP2020/073187
Publication Date:
April 22, 2021
Filing Date:
August 19, 2020
Export Citation:
Assignee:
MINA THERAPEUTICS LTD (GB)
LGC GENOMICS LTD (GB)
LGC GENOMICS LTD (GB)
International Classes:
A61K47/54; A61K31/713; A61P1/18; A61P3/06; A61P31/12; C07H15/04; C07H15/18; C07H15/26; C07H21/00; C12N15/113
Attorney, Agent or Firm:
HOFFMANN EITLE PATENT- UND RECHTSANWÄLTE PARTMBB (DE)
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