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Title:
OLIGONUCLEOTIDE DERIVATIVE, LABELING AGENT, AND USE OF THE LABELING AGENT
Document Type and Number:
WIPO Patent Application WO/2010/055789
Kind Code:
A1
Abstract:
Disclosed is an oligonucleotide derivative which is more suitable for practical use.  Also disclosed is a labeling agent.  Further disclosed is use of the labeling agent.  The labeling agent comprises multiple nucleotide derivative units each represented by formula (1) [wherein Z represents a nitrogen atom or CH; Y represents a non-fused aromatic hydrocarbon group or a fused polycyclic hydrocarbon group; X1 represents O, S or Se; and X2 represents SH (or S-), S, Se-, an alkyl group having 1 to 4 carbon atoms, or a morpholino group].

Inventors:
UENO YOSHIHITO (JP)
KITADE YUKIO (JP)
Application Number:
PCT/JP2009/068785
Publication Date:
May 20, 2010
Filing Date:
November 02, 2009
Export Citation:
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Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
UENO YOSHIHITO (JP)
KITADE YUKIO (JP)
International Classes:
C12N15/09; C07H21/02; C09B3/18; C09B57/00; C12Q1/68; G01N21/64; G01N33/533
Domestic Patent References:
WO2007094135A12007-08-23
WO2006027862A12006-03-16
WO2007094135A12007-08-23
Other References:
UENO, Y. ET AL.: "Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3'-overhang regions.", BIOORG.MED.CHEM. LETT., vol. 18, 1 October 2008 (2008-10-01), pages 5194 - 5196, XP025433897
UENO, Y. ET AL.: "Synthesis and Properties of Nucleic Acid Analogues Consisting of a Benzene- Phosphate Backbone.", J.ORG.CHEM., vol. 70, 2005, pages 7925 - 7935, XP003016648
UENO Y. ET AL.: "Synthesis and properties of DNA analogs consisting of the benzene-phosphate backbone.", NUCLEIC ACIDS SYMP.SER., no. 48, 2004, pages 17 - 18, XP008152446
WILSON, J.N. ET AL.: "Efficient Quenching of Oligomeric Fluorophores on a DNA Backbone.", J.AM. CHEM.SOC., vol. 129, 2007, pages 15426 - 15427, XP008152452
GAO, J. ET AL.: "Modified DNA Analogues That Sense Light Exposure with Color Changes.", J.AM.CHEM. SOC., vol. 126, 2004, pages 12748 - 12749, XP008152442
GAO, J. ET AL.: "Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides.", J.AM. CHEM.SOC., vol. 124, 2002, pages 11590 - 11591, XP008152454
SHINJI KOMATSUZAKI ET AL.: "Benzene-rin-san Kokkaku kara Naru Keiko Shikiso Shusekitai no Gosei to Seishitsu (1)", DAI 89 KAI ANNUAL MEETING OF CHEMICAL SOCIETY OF JAPAN IN SPRING KOEN YOKOSHU, no. 2, 13 March 2009 (2009-03-13), pages 1283, XP008160293
TETSUJI TAKASU ET AL.: "Benzene-rin-san Kokkaku kara Naru Keiko Shikiso Shusekitai no Gosei to Seishitsu (2)", DAI 89 KAI ANNUAL MEETING OF CHEMICAL SOCIETY OF JAPAN IN SPRING KOEN YOKOSHU, no. 2, 13 March 2009 (2009-03-13), pages 1283, XP008160294
See also references of EP 2366785A4
KOOL, J.A.C.S., vol. 129, 2007, pages 15426
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY
"Oligonucleotide Synthesis", 1984
"Nucleic Acid Hybridization", 1984
"Methods in Enzymology", ACADEMIC PRESS, INC.
Attorney, Agent or Firm:
KAI-U PATENT LAW FIRM (JP)
Patent business corporation KAI-U Patent Law Firm (JP)
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