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Title:
OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/133491
Kind Code:
A1
Abstract:
Provided are: an oligonucleotide having, at 5'-terminal thereof, a nucleotide or nucleoside residue represented by formula (I) {wherein X1 represents an oxygen atom or the like; R1 represents formula (IIA) (wherein R5A represents a halogen atom or the like; and R6A represents a hydrogen atom or the like), formula (IVA) (wherein Y3A represents a nitrogen atom or the like; and Y4A represents CH or the like) or the like; R2 represents a hydrogen atom, a hydroxy group, a halogen atom or a lower alkoxy group which may have a substituent; and R3 represents a hydrogen atom or formula (VI) (wherein n2 represents 1, 2 or 3)}, wherein the nucleotide or nucleoside residue is bound to an adjacent nucleotide residue through an oxygen atom that is located at position-3 in the nucleotide or nucleoside residue; and others.

Inventors:
SHINOHARA FUMIKAZU (JP)
MAKINO ASANA (JP)
YAMAMOTO JUNICHIRO (JP)
NAKAJIMA TAKAHIRO (JP)
OASHI TAIJI (JP)
SUZUKI MICHIHIKO (JP)
SAITO JUN-ICHI (JP)
NISHIKAWA TOMOYUKI (JP)
NAKOJI MASAYOSHI (JP)
TAKAHASHI YUICHI (JP)
KOUDA YASUO (JP)
Application Number:
PCT/JP2015/056249
Publication Date:
September 11, 2015
Filing Date:
March 03, 2015
Export Citation:
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Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C07H19/16; A61K31/7076; A61K31/713; A61K48/00; A61P43/00; C07H19/167; C07H19/173; C07H19/20; C12N15/113
Domestic Patent References:
WO2013090186A12013-06-20
WO2014034934A12014-03-06
Foreign References:
US5906918A1999-05-25
JPS5363399A1978-06-06
Other References:
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See also references of EP 3130597A4
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