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Title:
OLIGONUCLEOTIDES WITH ACTIVITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS
Document Type and Number:
WIPO Patent Application WO1995003407
Kind Code:
A3
Abstract:
The present invention features compounds and methods for inhibiting propagation of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize to a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a patient infected with HIV. Other uses of the present invention include detecting the presence of HIV by using the oligonucleotides as detection probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.

Inventors:
PETERSON TODD C
VELARDE JORGE JR
Application Number:
PCT/US1994/008407
Publication Date:
June 22, 1995
Filing Date:
July 19, 1994
Export Citation:
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Assignee:
GEN PROBE INC (US)
International Classes:
C12N15/09; A61K31/70; A61K48/00; A61P31/12; C07H21/00; C12N7/00; C12N15/113; (IPC1-7): C12N15/11; A61K31/70; C07H21/00
Domestic Patent References:
WO1991018004A11991-11-28
WO1995003406A21995-02-02
Foreign References:
EP0386563A11990-09-12
Other References:
LISZIEWICZ, J. ET AL.: "Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, WASHINGTON US, pages 3860 - 3864
AGRAWAL, S. ET AL.: "Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 86, WASHINGTON US, pages 7790 - 7794
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