Title:
OLIGOPEPTIDE LINKER INTERMEDIATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/077317
Kind Code:
A1
Abstract:
Provided are an oligopeptide linker intermediate and a preparation method therefor. The method has mild reaction conditions, almost no side reaction, few impurities, and the product is relatively pure and easy to purify.
Inventors:
LI LELE (CN)
HUANG CHANGJIANG (CN)
HUANG CHANGJIANG (CN)
Application Number:
PCT/CN2019/112671
Publication Date:
April 29, 2021
Filing Date:
October 23, 2019
Export Citation:
Assignee:
MABPLEX INT CO LTD (CN)
International Classes:
A61K47/64; C07K5/06; A61K47/68; A61P35/00; C07K1/02; C07K5/08; C07K5/10
Foreign References:
| CN108025084A | 2018-05-11 |
Other References:
ZHAOHUI LI: "Preparation and Preliminary Study on Biological Activities of Several Anti-CD 20Antibody- Druy Conjugates", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICAL AND HEALTH SCIENCES, 15 December 2013 (2013-12-15), pages 1 - 149, XP055732732
MONDAL, D. ET AL.: "Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research", TETRAHEDRON LETT., vol. 59, no. 40, 3 October 2018 (2018-10-03), pages 3594 - 3599, XP055732113
ORSO, A.D. ET AL.: "Protease-Cleavable Linkers Modulate the Anticancer Activity of Nonintemalizing Antibody-Drug Conjugates", TETRAHEDRON LETT., vol. 28, no. 7, 19 July 2017 (2017-07-19), pages 1826, XP055732115
ZHOU LIAN ,YU MEI-PING: "Synthesis of End N-Teoc Protected Amino Acid", ZHEJIANG CHEMICAL INDUSTRY, vol. 46, no. 5, 15 May 2015 (2015-05-15), pages 33 - 35, XP055732738, ISSN: 1006-4184
WANG YFAN SZHONG W ET AL.: "Development and properties of valine-alanine based antibody-drug conjugates with monomethyl auristatin e as the potent payload[J", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 9, 2017
MONDAL DFORD JPINNEY K G: "Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research [J", TETRAHEDRON LETTERS, vol. 59, no. 40, 2018, pages 3594 - 3599
MONDAL, D. ET AL.: "Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research", TETRAHEDRON LETT., vol. 59, no. 40, 3 October 2018 (2018-10-03), pages 3594 - 3599, XP055732113
ORSO, A.D. ET AL.: "Protease-Cleavable Linkers Modulate the Anticancer Activity of Nonintemalizing Antibody-Drug Conjugates", TETRAHEDRON LETT., vol. 28, no. 7, 19 July 2017 (2017-07-19), pages 1826, XP055732115
ZHOU LIAN ,YU MEI-PING: "Synthesis of End N-Teoc Protected Amino Acid", ZHEJIANG CHEMICAL INDUSTRY, vol. 46, no. 5, 15 May 2015 (2015-05-15), pages 33 - 35, XP055732738, ISSN: 1006-4184
WANG YFAN SZHONG W ET AL.: "Development and properties of valine-alanine based antibody-drug conjugates with monomethyl auristatin e as the potent payload[J", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 9, 2017
MONDAL DFORD JPINNEY K G: "Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research [J", TETRAHEDRON LETTERS, vol. 59, no. 40, 2018, pages 3594 - 3599
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