Title:
ORAL CORONAVIRUS INFECTION VACCINE
Document Type and Number:
WIPO Patent Application WO/2022/163647
Kind Code:
A1
Abstract:
Provided is a vaccine that can be administered orally against coronavirus infection. A vaccine that can be administered orally against coronavirus infection can be provided by transformed bifidobacteria designed so as to present some or all of the proteins that constitute the coronavirus on the bifidobacterium surface layer. Transformed bifidobacteria designed so as to present some or all of the proteins that constitute the coronavirus on the bifidobacterium surface layer induce humoral immunity and cellular immunity by oral administration and can suppress any increase in severity of pneumonia, etc., even after viral infection.
Inventors:
SHIRAKAWA TOSHIRO (JP)
UENO SHUNPEI (JP)
KITAGAWA KOICHI (JP)
KONDO AKIHIKO (JP)
KAMEOKA MASANORI (JP)
KATAYAMA TAKANE (JP)
UENO SHUNPEI (JP)
KITAGAWA KOICHI (JP)
KONDO AKIHIKO (JP)
KAMEOKA MASANORI (JP)
KATAYAMA TAKANE (JP)
Application Number:
PCT/JP2022/002677
Publication Date:
August 04, 2022
Filing Date:
January 25, 2022
Export Citation:
Assignee:
UNIV KOBE NAT UNIV CORP (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
C12N1/21; A61K35/745; A61K39/215; A61P31/14; A61P37/04; C07K14/165; C07K14/195; C07K19/00; C12N15/31; C12N15/50; C12N15/62
Domestic Patent References:
| WO2011034181A1 | 2011-03-24 | |||
| WO2016208332A1 | 2016-12-29 | |||
| WO2014129412A1 | 2014-08-28 |
Foreign References:
| CN111671890A | 2020-09-18 | |||
| JP2006526403A | 2006-11-24 | |||
| US20150056246A1 | 2015-02-26 | |||
| CN111944837A | 2020-11-17 | |||
| JP2021010009A | 2021-01-28 |
Other References:
DATABASE Protein NCBI; 28 March 2020 (2020-03-28), ANONYMOUS : "surface glycoprotein [Severe acute respiratory syndrome coronavirus 2]", XP055953771, Database accession no. BCB97891
MATHAVAN SARMILAH, KUMAR SURESH: "Evaluation of the Effect of D614g, N501y and S477n Mutation in Sars-Cov-2 through Computational Approach", PREPRINTS, MDPI, 28 December 2020 (2020-12-28), pages 1 - 33, XP055953773, [retrieved on 20220823], DOI: 10.20944/preprints202012.0710.v1
"GenBank", Database accession no. MT263387.1
SAKURAMA ET AL., JBC, vol. 288, 2013, pages 25194 - 25206
MATHAVAN SARMILAH, KUMAR SURESH: "Evaluation of the Effect of D614g, N501y and S477n Mutation in Sars-Cov-2 through Computational Approach", PREPRINTS, MDPI, 28 December 2020 (2020-12-28), pages 1 - 33, XP055953773, [retrieved on 20220823], DOI: 10.20944/preprints202012.0710.v1
"GenBank", Database accession no. MT263387.1
SAKURAMA ET AL., JBC, vol. 288, 2013, pages 25194 - 25206
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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