Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ORAL DELIVERY OF NANOPARTICLES FOR KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/231383
Kind Code:
A3
Abstract:
A drug delivery system for oral administration is provided. The drug delivery system includes an oral delivery carrier and a plurality of micelles attached to or dispersed in the oral delivery carrier. Each of the micelles includes a hydrophobic core and a hydrophilic corona targeted to a subject's kidney. A pharmaceutical payload is carried by the plurality of micelles. Another drug delivery system includes a plurality of micelles and a payload within each micelle. Each micelle has a kidney targeting peptide conjugated thereto with a polyethylene glycol linking group having a molecular weight less than 1800 Daltons.

Inventors:
CHUNG YOO EUN JI PAIGE (US)
WANG JONATHAN (US)
Application Number:
PCT/US2021/031714
Publication Date:
December 16, 2021
Filing Date:
May 11, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
International Classes:
A61K38/17; A61K38/00; A61P13/12
Foreign References:
US20130034602A12013-02-07
US20180318430A12018-11-08
Other References:
WANG JONATHAN; POON CHRISTOPHER; CHIN DEBORAH; MILKOWSKI SARAH; LU VIVIAN; HALLOWS KENNETH R.; CHUNG EUN JI: "Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery", NANO RESEARCH, TSINGHUA UNIVERSITY PRESS, CN, vol. 11, no. 10, 6 June 2018 (2018-06-06), CN , pages 5584 - 5595, XP036622766, ISSN: 1998-0124, DOI: 10.1007/s12274-018-2100-2
WANG J., HALLOWS K., CHUNG E.: "SUN-159 ORAL NANOCAPSULE FORMULATION FOR POLYCYSTIC KIDNEY DISEASE", KIDNEY INTERNATIONAL REPORTS, ELSEVIER INC., US, vol. 5, no. 3, 1 March 2020 (2020-03-01), US , pages S266, XP055884047, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2020.02.688
Attorney, Agent or Firm:
PROSCIA, James W. et al. (US)
Download PDF: