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Title:
ORGANIC ACID SALT OF NICOTINAMIDE RIBOSIDE, COMPOSITION THEREOF AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/196349
Kind Code:
A1
Abstract:
An organic acid salt of nicotinamide riboside; the organic acid is selected from malic acid, citric acid, royal jelly acid, and so on, and the molar ratio of nicotinamide riboside to organic acid is 1:2 or 1:1. A compound composition of the organic acid salt of nicotinamide riboside and a carrier, and the carrier is selected from nicotinic acid, glutamic acid, royal jelly acid, cervic acid, microcrystalline cellulose, or apple cider vinegar powder. Organic acids that are more acidic are used, and said organic acids form a close ion pair with nicotinamide riboside and have a certain degree of hydrophobicity so as to improve the stability of nicotinamide riboside. The carrier can prevent the penetration of water and improve the stability of the organic acid salt in water.

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Inventors:
YANG CHAOWEN (CN)
WANG LEI (CN)
SONG JIALIANG (CN)
FU DINGLIANG (CN)
Application Number:
PCT/CN2020/089566
Publication Date:
October 07, 2021
Filing Date:
May 11, 2020
Export Citation:
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Assignee:
SHENZHEN DIECKMANN TECH CO LTD (CN)
International Classes:
C07H19/048; A23L33/10; A23L33/175; C07C51/41; C07C59/245; C07C59/265; C07C59/42; C07H1/00
Domestic Patent References:
WO2019210607A12019-11-07
WO2019126482A12019-06-27
Foreign References:
CN105873937A2016-08-17
CN106715455A2017-05-24
CN108774278A2018-11-09
US20180362570A12018-12-20
Other References:
ALVAREZ RICARDO, SCHABERT GÜNTER, SOYDEMIR AYSEL, WICK LUKAS, SPITZ URS, SPINGLER BERNHARD: "Nicotinamide Riboside Derivatives: Single Crystal Growth and Determination of X-ray Structures", CRYSTAL GROWTH & DESIGN, vol. 19, no. 7, 3 July 2019 (2019-07-03), pages 4019 - 4028, XP055839025, ISSN: 1528-7483, DOI: 10.1021/acs.cgd.9b00423
Attorney, Agent or Firm:
REIZ LAW FIRM (CN)
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