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Title:
ORPHAN NUCLEAR RECEPTOR NUR77 LIGAND AND APPLICATION THEREOF 
Document Type and Number:
WIPO Patent Application WO/2018/006801
Kind Code:
A1
Abstract:
The present application relates to an orphan nuclear receptor Nur77 ligand and an application thereof. The application specifically relates to a compound represented by formula I and application of the compound as the orphan nuclear receptor Nur77 ligand. The application further relates to an application of the compound represented by formula I for preventing or treating a disease related to the orphan nuclear receptor Nur77.

Inventors:
ZHANG XIAOKUN (CN)
LIN XIANGZHI (CN)
SU YING (CN)
ZENG ZHIPING (CN)
HU MENGJIE (CN)
LUO QIANG (CN)
ZHU YI (CN)
GULIMIRAN ALITONGBIEKE (CN)
Application Number:
PCT/CN2017/091716
Publication Date:
January 11, 2018
Filing Date:
July 04, 2017
Export Citation:
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Assignee:
UNIV XIAMEN (CN)
International Classes:
A61K31/015; C07J63/00; A61K31/56; A61P3/04
Domestic Patent References:
WO2015148802A12015-10-01
WO2009067891A12009-06-04
WO2017070615A12017-04-27
Foreign References:
US20040220267A12004-11-04
CN105985401A2016-10-05
Other References:
HU , MENGJIE ET AL.: "Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy", MOLECULAR CELL, vol. 66, no. 1, 6 April 2017 (2017-04-06), pages 141 - 153, XP029970893, DOI: 10.1016/j.molcel.2017.03.008
KLAIC, L. ET AL.: "Remarkable Stereospecific Conjugate Additions to the Hsp90 Inhibitor Celastrol", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 16 November 2011 (2011-11-16), pages 19634 - 19637, XP055192971, DOI: doi:10.1021/ja208359a
HARADA, R. ET AL.: "STRUCTURE OF PRISTIWERIN, A QUINONOID TRITERPENE", TETRAHEDRON LETTERS, 31 December 1962 (1962-12-31), pages 603 - 607
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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