Title:
ORPHAN NUCLEAR RECEPTOR NUR77 LIGAND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/006801
Kind Code:
A1
Abstract:
The present application relates to an orphan nuclear receptor Nur77 ligand and an application thereof. The application specifically relates to a compound represented by formula I and application of the compound as the orphan nuclear receptor Nur77 ligand. The application further relates to an application of the compound represented by formula I for preventing or treating a disease related to the orphan nuclear receptor Nur77.
Inventors:
ZHANG XIAOKUN (CN)
LIN XIANGZHI (CN)
SU YING (CN)
ZENG ZHIPING (CN)
HU MENGJIE (CN)
LUO QIANG (CN)
ZHU YI (CN)
GULIMIRAN ALITONGBIEKE (CN)
LIN XIANGZHI (CN)
SU YING (CN)
ZENG ZHIPING (CN)
HU MENGJIE (CN)
LUO QIANG (CN)
ZHU YI (CN)
GULIMIRAN ALITONGBIEKE (CN)
Application Number:
PCT/CN2017/091716
Publication Date:
January 11, 2018
Filing Date:
July 04, 2017
Export Citation:
Assignee:
UNIV XIAMEN (CN)
International Classes:
A61K31/015; C07J63/00; A61K31/56; A61P3/04
Domestic Patent References:
WO2015148802A1 | 2015-10-01 | |||
WO2009067891A1 | 2009-06-04 | |||
WO2017070615A1 | 2017-04-27 |
Foreign References:
US20040220267A1 | 2004-11-04 | |||
CN105985401A | 2016-10-05 |
Other References:
HU , MENGJIE ET AL.: "Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy", MOLECULAR CELL, vol. 66, no. 1, 6 April 2017 (2017-04-06), pages 141 - 153, XP029970893, DOI: 10.1016/j.molcel.2017.03.008
KLAIC, L. ET AL.: "Remarkable Stereospecific Conjugate Additions to the Hsp90 Inhibitor Celastrol", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 16 November 2011 (2011-11-16), pages 19634 - 19637, XP055192971, DOI: doi:10.1021/ja208359a
HARADA, R. ET AL.: "STRUCTURE OF PRISTIWERIN, A QUINONOID TRITERPENE", TETRAHEDRON LETTERS, 31 December 1962 (1962-12-31), pages 603 - 607
KLAIC, L. ET AL.: "Remarkable Stereospecific Conjugate Additions to the Hsp90 Inhibitor Celastrol", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 16 November 2011 (2011-11-16), pages 19634 - 19637, XP055192971, DOI: doi:10.1021/ja208359a
HARADA, R. ET AL.: "STRUCTURE OF PRISTIWERIN, A QUINONOID TRITERPENE", TETRAHEDRON LETTERS, 31 December 1962 (1962-12-31), pages 603 - 607
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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