Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE &agr -AMINO-&epsiv -CAPROLACTAM OR SALT THEREOF AND INTERMEDIATE FOR THE PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2005/030730
Kind Code:
A1
Abstract:
An industrially advantageous production process which is an improved process for the production of an optically active &agr -amino-&epsiv -caprolactam (ACL). By the process, a desired optically active isomer having a high optical purity can be obtained with the aid of an optical resolver available at low cost in a large amount. An optically active phenylalanine derivative, in particular, N-p-toluenesulfonyl-L-phenylalanine, is used as a resolver to optically resolve DL-ACL by the diastereomeric method. A solvent having a permittivity suitably selected is used as a reaction medium for this optical resolution to precipitate a diastereomeric salt. Thus, a diastereomeric salt containing D-ACL or L-ACL can be selectively obtained.
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Inventors:
SAKAI KENICHI (JP)
SAKURAI RUMIKO (JP)
YUZAWA ATSUSHI (JP)
HATAHIRA KAORU (JP)
SAKURAI RUMIKO (JP)
YUZAWA ATSUSHI (JP)
HATAHIRA KAORU (JP)
Application Number:
PCT/JP2004/014186
Publication Date:
April 07, 2005
Filing Date:
September 28, 2004
Export Citation:
Assignee:
YAMAKAWA CHEMICAL IND (JP)
AJINOMOTO KK (JP)
SAKAI KENICHI (JP)
SAKURAI RUMIKO (JP)
YUZAWA ATSUSHI (JP)
HATAHIRA KAORU (JP)
AJINOMOTO KK (JP)
SAKAI KENICHI (JP)
SAKURAI RUMIKO (JP)
YUZAWA ATSUSHI (JP)
HATAHIRA KAORU (JP)
International Classes:
C07B57/00; C07D223/12; (IPC1-7): C07D223/12; C07B53/00
Foreign References:
| JPS62114970A | 1987-05-26 | |||
| JPS4839948B1 | 1973-11-28 | |||
| JPH0971571A | 1997-03-18 | |||
| JPS59110656A | 1984-06-26 | |||
| JPS5832872A | 1983-02-25 | |||
| JP2000290201A | 2000-10-17 | |||
| JPS62114945A | 1987-05-26 |
Attorney, Agent or Firm:
Suga, Fusao (311 Century Park Tower, 1-1, Tsukuda 2-chom, Chuo-ku Tokyo, JP)
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