Title:
PANAXOSIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2019/219098
Kind Code:
A1
Abstract:
Disclosed are a panaxoside derivative, a preparation method therefor, and an application. The compound shows a strong anti-inflammatory effect in vitro and in animal model experiments, and may therefore be used for preparing an anti-inflammatory drug, in particular for treating asthma and COPD. In experiments, the compound has a significant effect on asthma and COPD, and the efficacy in a high dose group is superior to dexamethasone and budesonide. At far more than the effective treatment dose, the compound does not have a significant effect on blood count or blood sugar. The compound has high application prospects in anti-inflammatory drugs, especially in the field of treating asthma and COPD.
Inventors:
LIU QUANHAI (CN)
ZHANG JUN (CN)
ZHANG JUN (CN)
Application Number:
PCT/CN2019/095992
Publication Date:
November 21, 2019
Filing Date:
July 15, 2019
Export Citation:
Assignee:
SUZHOU JI ER BIOLOGICAL MEDICINE CO LTD (CN)
International Classes:
C07J17/00; A61K31/7028; A61K31/7032; A61K31/704; A61P11/00; A61P11/06; A61P29/00
Foreign References:
| CN102796159A | 2012-11-28 | |||
| CN104586860A | 2015-05-06 | |||
| CN109553653A | 2019-04-02 |
Other References:
ATOPKINA L.N. ET AL.: "Synthesis of 20S-protopanaxadiol 20-0- P -D-glucopyra- noside, a metabolite ofPanax ginsengglycosides, and compounds related to it", CHEMISTRY OF NATURAL COMPOUNDS, vol. 42, no. 4, 1 July 2006 (2006-07-01), pages 452 - 458, XP019433975
DENG XU ET AL.: "Exploring of drug leads from diversity-oriented Mi- chael-acceptor library derived from natural products", NAT. PROD. BIOPROSPECT., vol. 2, no. 5, 4 December 2012 (2012-12-04), pages 210 - 216, XP055656018
LIAO JINXI ET AL.: "Synthesis of ginsenoside Rh2 and chikusetsusaponin- LT 8 via gold(I)-catalyzed glycosylation with a glycosyl ortho-alkynylbenzoate as donor", TETRAHEDRON LETTERS, vol. 52, no. 24, 1 June 2011 (2011-06-01), pages 3075 - 3077, XP055656065
REN SUMEI ET AL.: "Synthesis and biological evaluation of Ginsenoside Co- mpound K analogues as a novel class of anti-asthmatic agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 1, 9 November 2018 (2018-11-09), pages 51 - 55, XP085557010
DENG XU ET AL.: "Exploring of drug leads from diversity-oriented Mi- chael-acceptor library derived from natural products", NAT. PROD. BIOPROSPECT., vol. 2, no. 5, 4 December 2012 (2012-12-04), pages 210 - 216, XP055656018
LIAO JINXI ET AL.: "Synthesis of ginsenoside Rh2 and chikusetsusaponin- LT 8 via gold(I)-catalyzed glycosylation with a glycosyl ortho-alkynylbenzoate as donor", TETRAHEDRON LETTERS, vol. 52, no. 24, 1 June 2011 (2011-06-01), pages 3075 - 3077, XP055656065
REN SUMEI ET AL.: "Synthesis and biological evaluation of Ginsenoside Co- mpound K analogues as a novel class of anti-asthmatic agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 29, no. 1, 9 November 2018 (2018-11-09), pages 51 - 55, XP085557010
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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