Title:
PARATHYROID HORMONE DERIVATIVE IN DIMERIC FORM OF PARATHYROID HORMONE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF BONE DISEASES COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2020/222383
Kind Code:
A1
Abstract:
The present invention relates to a parathyroid hormone derivative in a dimeric form of a parathyroid hormone fragment and a pharmaceutical composition for the prevention or treatment of bone diseases comprising same. When administered to an animal model, the parathyroid hormone derivative in the dimeric form of the parathyroid hormone according to the present invention significantly increases bone density and enhances osteogenesis and thus can be effectively used for the treatment and prevention of bone diseases.
Inventors:
LEE SI HOON (KR)
Application Number:
PCT/KR2019/015078
Publication Date:
November 05, 2020
Filing Date:
November 07, 2019
Export Citation:
Assignee:
UNIV GACHON IND ACAD COOP FOUND (KR)
GIL MEDICAL CT (KR)
GIL MEDICAL CT (KR)
International Classes:
C07K14/635; A61K38/00; A61P19/08
Foreign References:
| KR101849701B1 | 2018-04-18 | |||
| US5849695A | 1998-12-15 |
Other References:
JIN, L. ET AL.: "Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 35, 2000, pages 27238 - 27244, XP002976117
REIDHAAR-OLSON, J. F ET AL.: "Active variants of human parathyroid hormone (1-34) with multiple amino acid substitutions", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 160, 2000, pages 135 - 147, XP002322157, DOI: 10.1016/S0303-7207(99)00211-7
DATABASE GenBank XP055756405, Database accession no. AAA00280.1
REIDHAAR-OLSON, J. F ET AL.: "Active variants of human parathyroid hormone (1-34) with multiple amino acid substitutions", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 160, 2000, pages 135 - 147, XP002322157, DOI: 10.1016/S0303-7207(99)00211-7
DATABASE GenBank XP055756405, Database accession no. AAA00280.1
Attorney, Agent or Firm:
LEE, Un Cheol (KR)
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