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Patent Searching and Data


Title:
PARTIAL OR FULL A1 AGONISTS - N<6> HETEROCYCLIC 5'-THIO SUBSTITUTED ADENOSINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001040243
Kind Code:
A3
Abstract:
N<6> heterocyclic 5' modified adenosine derivatives that are adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating central nervous system disorders, and treating diabetic disorders and obesity in mammals, and especially in humans.

Inventors:
ZABLOCKI JEFF A (US)
PALLE VENKATA P (US)
VARKHEDKAR VAIBHAV (US)
BELARDINELLI LUIZ (US)
Application Number:
PCT/US2000/042509
Publication Date:
December 13, 2001
Filing Date:
November 30, 2000
Export Citation:
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Assignee:
CV THERAPEUTICS INC (US)
ZABLOCKI JEFF A (US)
PALLE VENKATA P (US)
VARKHEDKAR VAIBHAV (US)
BELARDINELLI LUIZ (US)
International Classes:
C07H19/167; A61K9/08; A61K9/20; A61K31/7076; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P25/00; A61P25/08; A61P43/00; C07H19/16; (IPC1-7): C07H19/16; A61K31/7076; A61P9/00
Foreign References:
US5589467A1996-12-31
US5789416A1998-08-04
Other References:
E. VAN DER WENDEN ET AL.: "5'-Substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor", J. MED. CHEM., vol. 41, 1998, pages 102 - 108, XP002169792
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