Title:
PEARL SHELL WHITENING FACTOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/221145
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a pearl shell whitening factor, comprising the following steps of: clam shell crushing and sieving; performing mixing with a weak acid aqueous solution, stirring for decomposition, and a solid being separated, the solid being a crude protein; cleaning the crude protein using deionized water, performing mixing with a buffer solution and performing treatment by ultra-high pressure, and then reacting with a protease under ultrasound condition; inactivating enzyme and then filter pressing to obtain an aseptic filtered fluid; freezing and drying the filtered fluid; finally, obtaining freeze-dried powder. Further disclosed is use of the pearl shell whitening factor obtained by the method in the preparation of an endothelin antagonist.
Inventors:
WANG JING (CN)
YANG ANQUAN (CN)
ZHANG LIHUA (CN)
MO JIAHUAN (CN)
XIE MIN (CN)
YANG ANQUAN (CN)
ZHANG LIHUA (CN)
MO JIAHUAN (CN)
XIE MIN (CN)
Application Number:
PCT/CN2020/086910
Publication Date:
November 05, 2020
Filing Date:
April 26, 2020
Export Citation:
Assignee:
OSM BIOLOGY CO LTD (CN)
International Classes:
C12P21/06; A61Q19/02; C07K4/12
Foreign References:
| CN104688652A | 2015-06-10 | |||
| CN103804468A | 2014-05-21 | |||
| CN104911239A | 2015-09-16 | |||
| CN108066237A | 2018-05-25 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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