PEPTIDE CATALYST AND ALDEHYDE ASYMMETRIC α－AMINATION USING SAME

WIPO Patent Application WO/2013/024720

A1

　This catalyst is composed of a peptide and a carrier, said peptide containing an amino acid represented by formula (SAA)-(AA)-(AA2) or (SAA1)-(SAA)- (AA)- (AA2) at the N-terminus thereof. (In the formula, SAA, SAA1 independently represent an amino acid having a secondary amino group; AA represents a α,α－disubstituted amino acid; SAA2 represents one or two natural or non natural amino acids.) and the C-terminus thereof being bonded to the carrier and immobilized. In the presence of the peptide catalyst, an aldhehyde is reacted with a diazodicarboxylate derivative.

JP2015513562

Reaction product of hydrazine derivative and carbon dioxide

TANAKA TATSUYOSHI (JP)
AKAGAWA KENGO (JP)
KUDO KAZUAKI (JP)
MITSUDA MASARU (JP)

PCT/JP2012/069864

February 21, 2013

August 03, 2012

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KANEKA CORP (JP)
TANAKA TATSUYOSHI (JP)
AKAGAWA KENGO (JP)
KUDO KAZUAKI (JP)
MITSUDA MASARU (JP)

C07C281/02; B01J31/06; C07B61/00; C07K5/097; C07K5/117

MASSI, ALESSANDRO ET AL.: "Toward the optimization of continuous-flow aldol and a-amination reactions by means of proline-functionalized silicon packed-bed microreactors", TETRAHEDRON LETTERS, vol. 52, no. 5, 2011, pages 619 - 622
KOFOED, JACOB ET AL.: "Discovery of new peptide-based catalysts for the direct asymmetric aldol reaction", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 15, 2003, pages 2445 - 2447

UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)

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