Title:
PEPTIDE, AND CELL FUSION AGENT AND PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY CONTAINING SAID PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2021/054448
Kind Code:
A1
Abstract:
Purposes of the present invention include: providing an efficient cell fusion method; and providing a method for killing cancer cells through cell fusion. The purposes are achieved by: (1) a polypeptide having an amino acid sequence selected from the group consisting of amino acid sequences represented by SEQ ID NO: 1-8; or (2) a polypeptide having cell fusion activity and having an amino acid sequence obtained through deletion, substitution, insertion, and/or addition of 1-4 amino acid residues in the amino acid sequences represented by SEQ ID NO: 1-8.
Inventors:
KOGA MICHIKO (JP)
Application Number:
PCT/JP2020/035491
Publication Date:
March 25, 2021
Filing Date:
September 18, 2020
Export Citation:
Assignee:
KOGA MICHIKO (JP)
International Classes:
A61P35/00; A61K38/08; C07K4/00; C07K7/06; C07K14/00; C07K16/44; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/06; C12N15/11; C12N15/63
Foreign References:
| JPS5768790A | 1982-04-27 | |||
| JP2008523829A | 2008-07-10 | |||
| JP2007523829A | 2007-08-23 |
Other References:
MAJOREK, K. A. ET AL.: "Structural and immunologic characterization of bovine, horse, and rabbit serum albumins", MOL. IMMUNOL., vol. 52, 2012, pages 174 - 182, XP028427907, DOI: 10.1016/j.molimm.2012.05.011
UENO, HIRONAO, MASUKO TAKASHI, WANG JUE: "Epitope Mapping of Bovine Serum Albumin Using Monoclonal Antibodies Coupled with a Photoreactive Crosslinker", J. BIOCHEM., vol. 115, no. 6, 1994, pages 1119 - 1127, XP055805768, DOI: 10.1093/oxfordjournals.jbchem.a124467
HOOGENBOEZEM, E. N. ET AL.: "Harnessing albumin as a carrier for cancer therapies", ADV. DRUG DELIV. REV., vol. 130, 2018, pages 73 - 89, XP085451323, DOI: 10.1016/j.addr.2018.07.011
ZHAO, DONGMEI, ZHAO XIUHUA, ZU YUANGANG, LI JIALEI, ZHANG YU, JIANG RU, ZHANG ZHONGHUA: "Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles", INT. J. NANOMEDICINE, vol. 5, 2010, pages 669 - 677, XP055805793, DOI: 10.2147/IJN.S12918
ALI, SHAHIN S., SHAO JONATHAN, LARY DAVID J., KRONMILLER BRENT A., SHEN DANYU, STREM MARY D., AMOAKO-ATTAH ISHMAEL, AKROFI ANDREW : "Phytophthora megakarya and Phytophthora palmivora, Closely Related Causal Agents of Cacao Black Pod Rot, Underwent Increases in Genome Sizes and Gene Numbers by Different Mechanisms", GENOME BIOL. EVOL., vol. 9, no. 3, 1 March 2017 (2017-03-01), pages 536 - 557, XP055805796, DOI: 10.1093/gbe/evx021
DATABASE Nucleotide 2 February 2018 (2018-02-02), "Phytophthora palmivora var. palmivora strain sbr112.9 scaffold-20380, whole genome shotgun sequence", XP055805797, retrieved from NCBI Database accession no. NCKW01020374
VAN DE SANDE, LEEN, COSYNS SARAH, WILLAERT WOUTER, CEELEN WIM: "Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review", DRUG DELIVERY, vol. 27, no. 1, 1 January 2020 (2020-01-01), pages 40 - 53, XP055805804, DOI: 10.1080/10717544.2019.1704945
TAKAHASHI, TADANOBU ET AL.: "The 170th amino acid mutation in fusion glycoproteins of human parainfluenza virus type 1 induces multinucleated cell formation and caspase 3-dependent apoptosis", SEIKAGAKU = JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 83, no. 8, 30 November 2010 (2010-11-30), JP , pages 784 - 785, XP009535333, ISSN: 0037-1017
"Cell fusion", 1970, HARVARD UNIVERSITY PRESS
"Cell Fusion and some subcellular Properties of heterokaryons and hybrids", JOURNAL OF CELL BIOLOGY, vol. 67, 1975, pages 257 - 280
RAZ, E. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 9519 - 9523
DONNELLY, J. J. ET AL., J. INFECT. DIS., vol. 173, 1996, pages 314 - 320
KOHLER, G.MILSTEIN, C., NATURE, vol. 256, 1975, pages 495 - 497
CLACKSON, T. ET AL., NATURE, vol. 352, 1991, pages 624 - 628
ZEBEDEE, S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 3175 - 3179
LONBERG, N. ET AL., NATURE, vol. 368, 1994, pages 856 - 859
See also references of EP 4032589A4
UENO, HIRONAO, MASUKO TAKASHI, WANG JUE: "Epitope Mapping of Bovine Serum Albumin Using Monoclonal Antibodies Coupled with a Photoreactive Crosslinker", J. BIOCHEM., vol. 115, no. 6, 1994, pages 1119 - 1127, XP055805768, DOI: 10.1093/oxfordjournals.jbchem.a124467
HOOGENBOEZEM, E. N. ET AL.: "Harnessing albumin as a carrier for cancer therapies", ADV. DRUG DELIV. REV., vol. 130, 2018, pages 73 - 89, XP085451323, DOI: 10.1016/j.addr.2018.07.011
ZHAO, DONGMEI, ZHAO XIUHUA, ZU YUANGANG, LI JIALEI, ZHANG YU, JIANG RU, ZHANG ZHONGHUA: "Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles", INT. J. NANOMEDICINE, vol. 5, 2010, pages 669 - 677, XP055805793, DOI: 10.2147/IJN.S12918
ALI, SHAHIN S., SHAO JONATHAN, LARY DAVID J., KRONMILLER BRENT A., SHEN DANYU, STREM MARY D., AMOAKO-ATTAH ISHMAEL, AKROFI ANDREW : "Phytophthora megakarya and Phytophthora palmivora, Closely Related Causal Agents of Cacao Black Pod Rot, Underwent Increases in Genome Sizes and Gene Numbers by Different Mechanisms", GENOME BIOL. EVOL., vol. 9, no. 3, 1 March 2017 (2017-03-01), pages 536 - 557, XP055805796, DOI: 10.1093/gbe/evx021
DATABASE Nucleotide 2 February 2018 (2018-02-02), "Phytophthora palmivora var. palmivora strain sbr112.9 scaffold-20380, whole genome shotgun sequence", XP055805797, retrieved from NCBI Database accession no. NCKW01020374
VAN DE SANDE, LEEN, COSYNS SARAH, WILLAERT WOUTER, CEELEN WIM: "Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review", DRUG DELIVERY, vol. 27, no. 1, 1 January 2020 (2020-01-01), pages 40 - 53, XP055805804, DOI: 10.1080/10717544.2019.1704945
TAKAHASHI, TADANOBU ET AL.: "The 170th amino acid mutation in fusion glycoproteins of human parainfluenza virus type 1 induces multinucleated cell formation and caspase 3-dependent apoptosis", SEIKAGAKU = JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 83, no. 8, 30 November 2010 (2010-11-30), JP , pages 784 - 785, XP009535333, ISSN: 0037-1017
"Cell fusion", 1970, HARVARD UNIVERSITY PRESS
"Cell Fusion and some subcellular Properties of heterokaryons and hybrids", JOURNAL OF CELL BIOLOGY, vol. 67, 1975, pages 257 - 280
RAZ, E. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 9519 - 9523
DONNELLY, J. J. ET AL., J. INFECT. DIS., vol. 173, 1996, pages 314 - 320
KOHLER, G.MILSTEIN, C., NATURE, vol. 256, 1975, pages 495 - 497
CLACKSON, T. ET AL., NATURE, vol. 352, 1991, pages 624 - 628
ZEBEDEE, S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 3175 - 3179
LONBERG, N. ET AL., NATURE, vol. 368, 1994, pages 856 - 859
See also references of EP 4032589A4
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
Download PDF: