Title:
PHARMACEUTICAL AGENT FOR TRANSMUCOSAL ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2021/025020
Kind Code:
A1
Abstract:
Provided is a pharmaceutical agent that increases the efficiency of drug absorption through a mucosal epithelial layer. This pharmaceutical agent for transmucosal administration contains, as an active ingredient, a pharmaceutical agent compound to which a podocalyxin-targeting molecule is bonded.
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Inventors:
MISUMI SHOGO (JP)
KISHIMOTO NAOKI (JP)
MITSUMATA RYOTARO (JP)
KISHIMOTO NAOKI (JP)
MITSUMATA RYOTARO (JP)
Application Number:
PCT/JP2020/029836
Publication Date:
February 11, 2021
Filing Date:
August 04, 2020
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/745; A61K47/68; A61P1/04; A61P3/00; A61P3/06; A61P3/10; A61P5/00; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P11/08; A61P11/10; A61P11/14; A61P13/02; A61P19/10; A61P21/02; A61P23/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P29/02; A61P31/04; A61P31/12; A61P33/00; A61P37/04; A61P37/06; A61P37/08
Foreign References:
| JP2019512548A | 2019-05-16 | |||
| JP2018538356A | 2018-12-27 | |||
| JP2015520193A | 2015-07-16 |
Other References:
ANONYMOUS: "Human Podocalyxin PE-conjugated Antibody: Monoclonal Mouse IgG2A Clone # 222328; FAB1658P", R&D SYSTEMS, A BIOTECHNE BRAND; BIO-TECHNE PRODUCT DATASHEET, 2 June 2018 (2018-06-02), XP055791861, Retrieved from the Internet
SEKINE, SHIGERU ET AL.: "About new markers of renal disorder -Urinary podocyte, podocalyxin and clinicopathologic significance", THERAPEUTIC RESEARCH, vol. 29, no. 11, 2008, pages 1900 - 1904, XP008148139, ISSN: 0289-8020
S. MISUMI, M. MASUYAMA, N. TAKAMUNE, D. NAKAYAMA, R. MITSUMATA, H. MATSUMOTO, N. URATA, Y. TAKAHASHI, A. MUNEOKA, T. SUKAMOTO, K. : "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 182, no. 10, 15 May 2009 (2009-05-15), pages 6061 - 6070, XP055036259, ISSN: 00221767, DOI: 10.4049/jimmunol.0802928
SIZEMORE SCICEK MSIZEMORE NNG KPCASEY G: "Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin", CANCER RES., vol. 67, no. 13, 1 July 2007 (2007-07-01), pages 6183 - 91, XP055523000, DOI: 10.1158/0008-5472.CAN-06-3575
TAKEDA TMCQUISTAN TORLANDO RAFARQUHAR MG: "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton", J CLIN INVEST, vol. 108, no. 2, July 2001 (2001-07-01), pages 289 - 301
KAI HMOTOMURA YSAITO SHASHIMOTO KTATEFUJI TTAKAMUNE NMISUMI S: "Royal jelly enhances antigen-specific mucosal IgA response", FOOD SCI NUTR, vol. 1, no. 3, 6 March 2013 (2013-03-06), pages 222 - 227, XP055689695, DOI: 10.1002/fsn3.29
SEKINE, SHIGERU ET AL.: "About new markers of renal disorder -Urinary podocyte, podocalyxin and clinicopathologic significance", THERAPEUTIC RESEARCH, vol. 29, no. 11, 2008, pages 1900 - 1904, XP008148139, ISSN: 0289-8020
S. MISUMI, M. MASUYAMA, N. TAKAMUNE, D. NAKAYAMA, R. MITSUMATA, H. MATSUMOTO, N. URATA, Y. TAKAHASHI, A. MUNEOKA, T. SUKAMOTO, K. : "Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer", THE JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, vol. 182, no. 10, 15 May 2009 (2009-05-15), pages 6061 - 6070, XP055036259, ISSN: 00221767, DOI: 10.4049/jimmunol.0802928
SIZEMORE SCICEK MSIZEMORE NNG KPCASEY G: "Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin", CANCER RES., vol. 67, no. 13, 1 July 2007 (2007-07-01), pages 6183 - 91, XP055523000, DOI: 10.1158/0008-5472.CAN-06-3575
TAKEDA TMCQUISTAN TORLANDO RAFARQUHAR MG: "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton", J CLIN INVEST, vol. 108, no. 2, July 2001 (2001-07-01), pages 289 - 301
KAI HMOTOMURA YSAITO SHASHIMOTO KTATEFUJI TTAKAMUNE NMISUMI S: "Royal jelly enhances antigen-specific mucosal IgA response", FOOD SCI NUTR, vol. 1, no. 3, 6 March 2013 (2013-03-06), pages 222 - 227, XP055689695, DOI: 10.1002/fsn3.29
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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