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Title:
PHARMACEUTICAL COMBINATIONS OF PHTHALAZINE VEGF INHIBITORS AND BENZAMIDE HDAC INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004058234
Kind Code:
A3
Abstract:
Pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at least one compound of general formula II) or IIa), or pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at least one compound of general formula II) or IIa), and an anti-hormone, and their use for the treatment of different diseases resulting by persistent angiogenesis are described.

Inventors:
SCHUPPAN DETLEF (DE)
HEROLD CHRISTOPH (DE)
GANSMAYER MARION (DE)
OCKER MATTHIAS (DE)
THIERAUCH KARL-HEINZ (DE)
Application Number:
PCT/EP2003/014071
Publication Date:
January 12, 2006
Filing Date:
December 11, 2003
Export Citation:
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Assignee:
SCHERING AG (DE)
SCHUPPAN DETLEF (DE)
HEROLD CHRISTOPH (DE)
GANSMAYER MARION (DE)
OCKER MATTHIAS (DE)
THIERAUCH KARL-HEINZ (DE)
International Classes:
A61K31/00; A61K31/44; A61K31/4406; A61K31/501; A61K31/502; (IPC1-7): A61K31/502; A61K31/44; A61P35/00
Domestic Patent References:
WO1998035958A11998-08-20
WO2002090346A12002-11-14
WO2003022282A12003-03-20
WO2003028711A22003-04-10
WO2003059354A22003-07-24
Foreign References:
EP0847992A11998-06-17
Other References:
KIM M S ET AL: "Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes.", NATURE MEDICINE. APR 2001, vol. 7, no. 4, April 2001 (2001-04-01), pages 437 - 443, XP002278083, ISSN: 1078-8956
DEROANNE CHRISTOPHE F ET AL: "Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling.", ONCOGENE. 17 JAN 2002, vol. 21, no. 3, 17 January 2002 (2002-01-17), pages 427 - 436, XP002278084, ISSN: 0950-9232
ZGOURAS D ET AL: "Modulation of angiogenesis-related protein synthesis by valproic acid", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 316, no. 3, 9 April 2004 (2004-04-09), pages 693 - 697, XP004495942, ISSN: 0006-291X
SASAKAWA YUKA ET AL: "Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors.", BIOCHEMICAL PHARMACOLOGY. 15 SEP 2003, vol. 66, no. 6, 15 September 2003 (2003-09-15), pages 897 - 906, XP002278085, ISSN: 0006-2952
NAM NGUYEN-HAI ET AL: "Current targets for anticancer drug discovery.", CURRENT DRUG TARGETS. FEB 2003, vol. 4, no. 2, February 2003 (2003-02-01), pages 159 - 179, XP009029986, ISSN: 1389-4501
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