Title:
PHARMACEUTICAL COMPOSITION COMPRISING NOVEL AZOLOPYRIMIDINE HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/190073
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of cancer comprising a novel azolopyrimidine heterocyclic compound as an active ingredient, and the pharmaceutical composition for the prophylaxis or treatment of cancer of the present invention can be used as a small molecular immunotherapy anticancer agent which modulates an adenosine pathway by comprising the azolopyrimidien heterocyclic compound.
Inventors:
PARK SEONG JUN (KR)
LEE CHANG HOON (KR)
LIM HWAN JUNG (KR)
LEE CHANG HOON (KR)
LIM HWAN JUNG (KR)
Application Number:
PCT/KR2020/003827
Publication Date:
September 24, 2020
Filing Date:
March 20, 2020
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07H23/00; A61K31/357; A61K31/7076; A61P35/00; C07D493/04; C07H19/167
Domestic Patent References:
| WO2018049145A1 | 2018-03-15 | |||
| WO2015164573A1 | 2015-10-29 |
Foreign References:
| KR20180041222A | 2018-04-23 |
Other References:
EPPLE, ROBERT, KUDIRKA ROMAS, GREENBERG WILLIAM A.: "Solid-Phase Synthesis of Nucleoside Analogues", J. COMB. CHEM, vol. 5, no. 3, 2003, pages 292 - 310, XP055741803, DOI: 10.1021/cc020087f
KUNG, P.-P. ET AL.: "Design, synthesis, and biological evaluation of novel human 5'-deoxy-5' -methylthioadenosine phosphorylase (MTAP) substrates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 2829 - 2833, XP025313694, DOI: 10.1016/j.bmcl.2005.03.107
FRONT PHARMACOL, vol. 9, 1 March 2018 (2018-03-01), pages 153
See also references of EP 3939988A4
KUNG, P.-P. ET AL.: "Design, synthesis, and biological evaluation of novel human 5'-deoxy-5' -methylthioadenosine phosphorylase (MTAP) substrates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 2829 - 2833, XP025313694, DOI: 10.1016/j.bmcl.2005.03.107
FRONT PHARMACOL, vol. 9, 1 March 2018 (2018-03-01), pages 153
See also references of EP 3939988A4
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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