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Title:
PHARMACEUTICAL COMPOSITION CONTAINING ANTI-KIAA1114 ANTIBODY AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER INDUCED BY KIAA1114 OVER-EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2013/077618
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition containing an anti-KIAA1114 antibody as an active ingredient for the prevention or treatment of cancer induced by KIAA1114 over-expression. The anti-KIAA1114 antibody of the present invention specifically binds to an extracellular domain of a KIAA1114 protein, specifically reacts with various cancer cell lines and remarkably represses metastasis of cancer in vivo in a lung metastasis animal model using a KIAA1114 over-expression cancer cell line. Therefore, the anti-KIAA1114 antibody of the present invention can be effectively used for the prevention or treatment of cancer - particularly metastatic cancer, which is caused by KIAA1114 over-expression.

Inventors:
SUNG YOUNG CHUL (KR)
KIM SAE WON (KR)
YANG SE HWAN (KR)
Application Number:
PCT/KR2012/009843
Publication Date:
May 30, 2013
Filing Date:
November 20, 2012
Export Citation:
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Assignee:
GENEXINE CO LTD (KR)
International Classes:
A61K39/395; A61P35/00
Foreign References:
Other References:
DAITA NADANO ET AL., BIOLOGY OF REPRODUCTION, vol. 66, 2002, pages 313 - 321
BRAD STONE ET AL., GENE, vol. 267, 2001, pages 173 - 182
Attorney, Agent or Firm:
ERUUM PATENT LAW FIRM (KR)
특허법인 이룸 (KR)
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Claims: