Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION CONTAINING MELASTOMA SANGUINEUM EXTRACTS OR FRACTIONS THEREOF AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING DIABETIC COMPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2012/026748
Kind Code:
A3
Abstract:
The present invention relates to a composition containing Melastoma sanguineum extracts or fractions thereof as active ingredients for preventing or treating diabetic complications. More particularly, Melastoma sanguineum extracts, or ethyl acetate fractions and n-butanol fractions which are systematic fractions thereof, inhibit the formation of advanced glycation end-products as well as the activity of aldose reductases, which may serve as an index of the onset of diabetic complications. The Melastoma sanguineum extracts or ethyl acetate fractions and n-butanol fractions have the effects of potently inhibiting vasodilatation caused by hyperglycemia in zebrafish, which are vertebrates, and inhibiting diabetic complications when administered to animal models for diabetic disease. Therefore, the Melastoma sanguineum extracts or ethyl acetate fractions and n-butanol fractions, which are systematic fractions thereof, according to the present invention may be used as active ingredients for a pharmaceutical composition for preventing and treating diabetic complications.

Inventors:
KIM JIN SOOK (KR)
KIM JUNGHYUN (KR)
KIM CHAN-SIK (KR)
KIM YOUNG SOOK (KR)
KIM OHN SOON (KR)
KIM KI MO (KR)
SHON EUNJIN (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
Application Number:
PCT/KR2011/006231
Publication Date:
May 10, 2012
Filing Date:
August 23, 2011
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
KIM JIN SOOK (KR)
KIM JUNGHYUN (KR)
KIM CHAN-SIK (KR)
KIM YOUNG SOOK (KR)
KIM OHN SOON (KR)
KIM KI MO (KR)
SHON EUNJIN (KR)
JUNG DONG HO (KR)
LEE YUN MI (KR)
International Classes:
A61K36/185; A61P3/00; A61P3/10
Foreign References:
JP2006069939A2006-03-16
US20080199488A12008-08-21
Other References:
T. TANG ET AL.: "Comparison of flavonoids in medicinal plants Melastoma", JOURNAL OF CHINESE MEDICINAL MATERIALS, vol. 30, no. 8, August 2007 (2007-08-01), pages 912 - 913
Attorney, Agent or Firm:
LEE, Won Hee (642-16 Yoksam-don, Kangnam-ku Seoul 135-080, KR)
Download PDF:
Claims: