Title:
PHARMACEUTICAL COMPOSITION CONTAINING TAMSULOSIN HYDROCHLORIDE WITH EXCELLENT ACID RESISTANCE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/130385
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition containing tamsulosin hydrochloride with excellent acid resistance and a preparation method therefor, and to a pharmaceutical composition in which, by coating prepared core beads, which comprise tamsulosin hydrochloride as an active ingredient, with an enteric coating liquid prepared using a certain amount of a plasticizer, adding a buffer base and the like to adjust density, and then mixing and tableting a mixed portion and a lubricant, even after the tableting, the enteric coating is not broken and acid resistance is maintained. Thus, the present invention has good tabletability, excellent content uniformity, excellent acid resistance due to a low dissolution rate of tamsulosin hydrochloride, and no significant decomposition of tamsulosin hydrochloride, and thus, stability can be ensured.
Inventors:
HA EUN HO (KR)
LEE SEUNG JUN (KR)
IM HO TAEK (KR)
KIM YONG IL (KR)
LEE SEUNG JUN (KR)
IM HO TAEK (KR)
KIM YONG IL (KR)
Application Number:
PCT/KR2019/016280
Publication Date:
June 25, 2020
Filing Date:
November 25, 2019
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
A61K9/20; A61K9/50; A61K31/18
Domestic Patent References:
WO2005053659A1 | 2005-06-16 |
Foreign References:
KR20110122504A | 2011-11-10 | |||
KR20050112599A | 2005-12-01 | |||
KR20110113940A | 2011-10-19 | |||
KR20070044911A | 2007-05-02 | |||
KR100745515B1 | 2007-08-02 | |||
KR20170073580A | 2017-06-28 | |||
KR20180008339A | 2018-01-24 |
Other References:
See also references of EP 3881832A4
Attorney, Agent or Firm:
KIM, Byeong Pil (KR)
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