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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEMYELINATING DISEASE, COMPRISING KINASE INHIBITOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/243971
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating demyelinating disease, comprising as an active ingredient a kinase inhibitor that has been confirmed to promote motility recovery and oligodendrocyte regeneration in demyelinating disease-induced zebrafish. The present invention is expected to overcome the limitations of currently developed treatments for demyelinating disease, which simply relieve secondary symptoms caused by the disease, and to contribute to the fundamental treatment of demyelinating disease.

Inventors:
PARK HAE CHUL (KR)
LEE YUNKYOUNG (KR)
KIM SUHYUN (KR)
CHOI YONGMUN (KR)
SONG MYUNG JIN (KR)
KIM PANSOO (KR)
JEONG KWIWAN (KR)
Application Number:
PCT/KR2023/008064
Publication Date:
December 21, 2023
Filing Date:
June 12, 2023
Export Citation:
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Assignee:
UNIV KOREA RES & BUS FOUND (KR)
GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR)
International Classes:
A61K31/341; A61K31/353; A61K31/4709; A61K31/517; A61P25/00
Foreign References:
KR20210044212A2021-04-22
KR20210063443A2021-06-01
KR20120011042A2012-02-06
KR20210054741A2021-05-14
KR20210138783A2021-11-19
Other References:
OLIVER CRESPO; STACEY C. KANG; RICHARD DANEMAN; TAMSIN M. LINDSTROM; PEGGY P. HO; RAYMOND A. SOBEL; LAWRENCE STEINMAN; WILLIAM H. : "Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis", JOURNAL OF CLINICAL IMMUNOLOGY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 31, no. 6, 17 August 2011 (2011-08-17), Ne , pages 1010 - 1020, XP019983573, ISSN: 1573-2592, DOI: 10.1007/s10875-011-9579-6
ROTSTEIN DALIA L, SAWICKA KATHERINE, BHARATHA ADITYA, MONTALBAN XAVIER, LIPTON JEFFREY H: "CNS demyelination after initiating the tyrosine kinase inhibitor imatinib: A report of two cases", MULTIPLE SCLEROSIS JOURNAL, SAGE, US, vol. 26, no. 9, 1 August 2020 (2020-08-01), US , pages 1121 - 1124, XP093117326, ISSN: 1352-4585, DOI: 10.1177/1352458519892914
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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