PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FAMILIAL ADENOMATOUS POLYPOSIS, COMPRISING NICLOSAMIDE AND METFORMIN

WIPO Patent Application WO/2021/075645

A1

The present invention relates to a pharmaceutical composition for treating familial adenomatous polyposis by concomitantly administering niclosamide or a pharmaceutically acceptable salt thereof, and metformin or a pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention shows a significant synergy effect for preventing or treating familial adenomatous polyposis, due to the concomitant administration of niclosamide or a pharmaceutically acceptable salt thereof, and metformin or a pharmaceutically acceptable salt thereof.

KIM TAE IL (KR)
YOOK JONG IN (KR)
KIM NAM HEE (KR)
KIM HYUN SIL (KR)
CHOI JIWON (KR)

PCT/KR2020/002935

April 22, 2021

February 28, 2020

Click for automatic bibliography generation  

BAOBAB AIBIO CO LTD (KR)

A61K31/167; A61K31/155; A61P1/00

KR20180081936A	2018-07-18
KR20140096222A	2014-08-05
KR20140038898A	2014-03-31

AHN SUNG YONG, KIM NAM HEE, LEE KYUNGRO, CHA YONG HOON, YANG JI HYE, CHA SO YOUNG, CHO EUNAE SANDRA, LEE YOONMI, CHA JEONG SEOK, C: "Niclosamide is a potential therapeutic for familial adenomatos is polyposis by disrupting Axin-GSK3 interaction", ONCOTARGET, vol. 8, no. 19, 9 May 2017 (2017-05-09), pages 31842 - 31855, XP055818421
HIGURASHI, T. ET AL.: "Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial", BMC CANCE R, vol. 12, 2012, pages 118, XP021124917, DOI: 10.1186/1471-2407-12-118

PHIL & ONZI INT'L PATENT & LAW FIRM (KR)

View/Download PDF      PDF Help

Previous Patent: DISCHARGE APPARATUS FOR ENABLING SELECTION OR MIXING RATIO CONTROL OF EXTINGUISHING AGENTS

Next Patent: COMPTON IMAGING APPARATUS AND SINGLE PHOTON EMISSION AND POSITRON EMISSION TOMOGRAPHY SYSTEM COMPRIS...