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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE OR PAIN, COMPRISING MESENCHYMAL STEM CELLS EXPRESSING PTX-3, TIMP1 AND BDNF AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/158698
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prevention or treatment of inflammatory disease, comprising mesenchymal stem cells expressing PTX-3, TIMP1 and BDNF as an active ingredient. The mesenchymal stem cells expressing PTX-3, TIMP1, BDNF and/or HLA-A2, according to the present invention, may inhibit an inflammatory response by reducing the expressions of the inflammatory cytokines IL-1b, IL-6, IL-8 and TNF-a, and increasing the expressions of the anti-inflammatory cytokines IL-10 and arginase-1 (ARG-1), and may relieve pain caused by osteoarthritis when administered in an osteoarthritis-induced rat. Thus, the mesenchymal stem cells expressing PTX-3, TIMP1 and BDNF of the present invention may be usefully employed in the prevention, alleviation or treatment of inflammatory disease, pain, and pain caused by inflammation.

Inventors:
YANG YUN SUN (KR)
OH WONIL (KR)
CHOI SOO JIN (KR)
JIN HEY JIN (KR)
BAE YUN KYUNG (KR)
SONG BO RAM (KR)
LEE MINJU (KR)
Application Number:
PCT/KR2021/017772
Publication Date:
July 28, 2022
Filing Date:
November 29, 2021
Export Citation:
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Assignee:
MEDIPOST CO LTD (KR)
International Classes:
A61K35/28; A61K38/16; A61K38/18; A61P29/00; C12N5/0775
Foreign References:
KR20170122650A2017-11-06
KR20200124205A2020-11-02
KR20190109389A2019-09-25
Other References:
KIM MIYEON, KWON JI HYE, BAE YUN KYUNG, KIM GEE-HYE, UM SOYOUN, HA JUEUN, CHOI SOO JIN, OH WONIL, JIN HYE JIN: "Soluble PTX3 of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuates Hyperoxic Lung Injury by Activating Macrophage Polarization in Neonatal Rat Model", STEM CELLS INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, US, vol. 2020, 23 January 2020 (2020-01-23), US , pages 1 - 18, XP055953640, ISSN: 1687-966X, DOI: 10.1155/2020/1802976
CAPPUZZELLO CLAUDIA, DONI ANDREA, DANDER ERICA, PASQUALINI FABIO, NEBULONI MANUELA, BOTTAZZI BARBARA, MANTOVANI ALBERTO, BIONDI AN: "Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 136, no. 1, 1 January 2016 (2016-01-01), NL , pages 293 - 300, XP055953643, ISSN: 0022-202X, DOI: 10.1038/JID.2015.346
SHIRAKI AYA, KOTOOKA NORIHIKO, KOMODA HIROSHI, HIRASE TETSUAKI, OYAMA JUN-ICHI, NODE KOICHI: "Pentraxin-3 regulates the inflammatory activity of macrophages", BIOCHEMISTRY AND BIOPHYSICS REPORTS, ELSEVIER, vol. 5, 14 January 2016 (2016-01-14), pages 290 - 295, XP055953644, ISSN: 2405-5808, DOI: 10.1016/j.bbrep.2016.01.009
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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