Title:
PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING VACCINIA VIRUS AND GRANULOPOIESIS INHIBITOR AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2021/040496
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising a vaccinia virus and a granulopoiesis inhibitor as active ingredients. The pharmaceutical composition for treating cancer, comprising a vaccinia virus and a granulopoiesis inhibitor as active ingredients, of the present invention has a superior anticancer effect and safety compared to the case of administering only the existing vaccinia virus. Therefore, the pharmaceutical composition comprising a vaccinia virus and a granulopoiesis inhibitor as active ingredients of the present invention can be efficiently utilized in treating cancer.
Inventors:
HWANG TAE-HO (KR)
CHO MONG (KR)
KIM JAE-JOON (KR)
CHO MONG (KR)
KIM JAE-JOON (KR)
Application Number:
PCT/KR2020/011648
Publication Date:
March 04, 2021
Filing Date:
August 31, 2020
Export Citation:
Assignee:
BIONOXX INC (KR)
International Classes:
A61K35/768; A61K31/17; A61K31/454; A61K31/4985; A61K31/519; A61K45/06; A61P35/00
Foreign References:
| KR20190080806A | 2019-07-08 | |||
| US20120114612A1 | 2012-05-10 | |||
| KR20140123436A | 2014-10-22 |
Other References:
ELISABETH HOFMANN;STEPHANIE WEIBEL;ALADAR A SZALAY: "Combination treatment with oncolytic Vaccinia virus and cyclophosphamide results in synergistic antitumor effects in human lung adenocarcinoma bearing mice", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 12, no. 1, 17 July 2014 (2014-07-17), pages 197, XP021194808, ISSN: 1479-5876, DOI: 10.1186/1479-5876-12-197
HEINEMANN LUCY, SIMPSON GUY R, ANNELS NICOLA E, VILE RICHARD, MELCHER ALAN, PRESTWICH ROBIN, HARRINGTON KEVIN J, PANDHA HARDEV S: "The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis", MOLECULAR THERAPY, NO LONGER PUBLISHED BY ELSEVIER, vol. 18, no. 12, 1 December 2010 (2010-12-01), pages 2085 - 2093, XP055785603, ISSN: 1525-0016, DOI: 10.1038/mt.2010.189
LIAO Y ET AL., PLOS ONE, vol. 8, no. 7, 2013
"GenBank", Database accession no. AAA03056.1
See also references of EP 4023235A4
HEINEMANN LUCY, SIMPSON GUY R, ANNELS NICOLA E, VILE RICHARD, MELCHER ALAN, PRESTWICH ROBIN, HARRINGTON KEVIN J, PANDHA HARDEV S: "The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis", MOLECULAR THERAPY, NO LONGER PUBLISHED BY ELSEVIER, vol. 18, no. 12, 1 December 2010 (2010-12-01), pages 2085 - 2093, XP055785603, ISSN: 1525-0016, DOI: 10.1038/mt.2010.189
LIAO Y ET AL., PLOS ONE, vol. 8, no. 7, 2013
"GenBank", Database accession no. AAA03056.1
See also references of EP 4023235A4
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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