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Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING MALIGNANT BREAST CANCER
Document Type and Number:
WIPO Patent Application WO/2022/164269
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating or preventing malignant breast cancer and, more particularly, to a composition for transdifferentiation of ER-negative breast cancer to luminal breast cancer, comprising an HDAC1/2 inhibitor and a BCL11A inhibitor as active ingredients, and use of the composition. According to the present invention, when target genes of the present invention are inhibited, BLT is induced so that basal-like or triplet-negative breast cancer is transdifferentiated to luminal A subtype breast cancer which is responsive to anticancer therapy, that is, being curable by hormone therapy. Accordingly, an effective and novel drug treatment that has not been conventionally attempted may be provided, thereby not only increasing the survival rate of patients through targeted therapy by realizing personalized medicine, but also contributing to an improvement in the quality of life that results from unnecessary anticancer drug therapy.

Inventors:
CHO, Kwang Hyun (KR)
CHOI, Sea Rom (KR)
HWANG, Chae Young (KR)
LEE, Jong Hoon (KR)
Application Number:
PCT/KR2022/001622
Publication Date:
August 04, 2022
Filing Date:
January 28, 2022
Export Citation:
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Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR)
International Classes:
A61K48/00; A61K31/7105; A61K38/15; A61K31/138; A61K45/06; A61P35/00; A23L33/13; A23L33/18
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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