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Title:
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2014/178381
Kind Code:
A1
Abstract:
 Provided is a new compound having glycogen synthase activation potency, but minimal activation of receptor PPAR, and a high degree of safety. A compound represented by general formula [I], or a pharmaceutically acceptable salt thereof. (In the formula, Ar1 is a ring represented by either [II] or [III], R2 represents an alkyl group, R3 represents a hydrogen atom or an alkyl group, and R1 represents the substituent [IV] or [V].)

Inventors:
MATSUMOTO KAYO (JP)
MIYANAGA WATARU (JP)
DOHI MIZUKI (JP)
NAKAGAWA TADAKIYO (JP)
KOBAYASHI KAORI (JP)
TAKESHITA SEN (JP)
Application Number:
PCT/JP2014/061893
Publication Date:
November 06, 2014
Filing Date:
April 28, 2014
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
International Classes:
C07C323/18; A61K31/198; A61K31/275; A61K31/343; A61K31/351; A61K31/40; A61K31/401; A61K31/4025; A61K31/4402; A61K31/4409; A61K31/4525; A61P3/10; A61P43/00; C07D207/16; C07D211/34; C07D211/58; C07D213/56; C07D231/12; C07D239/26; C07D249/08; C07D263/32; C07D271/06; C07D277/20; C07D277/30; C07D295/14; C07D295/18; C07D307/79; C07D309/06; C07D333/48; C07D405/12; C07D407/12
Domestic Patent References:
WO2013065835A12013-05-10
WO2011058154A12011-05-19
WO2005000781A12005-01-06
WO2006058648A22006-06-08
WO2011057956A12011-05-19
WO2011057959A12011-05-19
WO2011057993A12011-05-19
WO2011058122A12011-05-19
WO2011058154A12011-05-19
WO2011067174A12011-06-09
WO2011067266A12011-06-09
Other References:
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (IGAKU NO AYUMI, vol. 220, no. 1, 2007, pages 75 - 80
TETRAHEDRON LETT., vol. 43, 2002, pages 1597 - 1598
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 1995, pages 12953 - 12956
ANALYTICAL BIOCHEMISTRY, vol. 261, 1998, pages 159 - 163
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
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