Title:
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2014/178381
Kind Code:
A1
Abstract:
Provided is a new compound having glycogen synthase activation potency, but minimal activation of receptor PPAR, and a high degree of safety. A compound represented by general formula [I], or a pharmaceutically acceptable salt thereof. (In the formula, Ar1 is a ring represented by either [II] or [III], R2 represents an alkyl group, R3 represents a hydrogen atom or an alkyl group, and R1 represents the substituent [IV] or [V].)
Inventors:
MATSUMOTO KAYO (JP)
MIYANAGA WATARU (JP)
DOHI MIZUKI (JP)
NAKAGAWA TADAKIYO (JP)
KOBAYASHI KAORI (JP)
TAKESHITA SEN (JP)
MIYANAGA WATARU (JP)
DOHI MIZUKI (JP)
NAKAGAWA TADAKIYO (JP)
KOBAYASHI KAORI (JP)
TAKESHITA SEN (JP)
Application Number:
PCT/JP2014/061893
Publication Date:
November 06, 2014
Filing Date:
April 28, 2014
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C07C323/18; A61K31/198; A61K31/275; A61K31/343; A61K31/351; A61K31/40; A61K31/401; A61K31/4025; A61K31/4402; A61K31/4409; A61K31/4525; A61P3/10; A61P43/00; C07D207/16; C07D211/34; C07D211/58; C07D213/56; C07D231/12; C07D239/26; C07D249/08; C07D263/32; C07D271/06; C07D277/20; C07D277/30; C07D295/14; C07D295/18; C07D307/79; C07D309/06; C07D333/48; C07D405/12; C07D407/12
Domestic Patent References:
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Other References:
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (IGAKU NO AYUMI, vol. 220, no. 1, 2007, pages 75 - 80
TETRAHEDRON LETT., vol. 43, 2002, pages 1597 - 1598
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 1995, pages 12953 - 12956
ANALYTICAL BIOCHEMISTRY, vol. 261, 1998, pages 159 - 163
TETRAHEDRON LETT., vol. 43, 2002, pages 1597 - 1598
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 22, 1995, pages 12953 - 12956
ANALYTICAL BIOCHEMISTRY, vol. 261, 1998, pages 159 - 163
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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