Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2019/132021
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition capable of significantly inhibiting ABH8 gene expression. Provided is a pharmaceutical composition that includes: a liposome containing a cationic lipid; and an antisense nucleic acid against an ABH8 gene transcription product or a portion thereof.
Inventors:
TSUJIKAWA KAZUTAKE (JP)
NAITO TOMOHARU (JP)
HIGUCHI TAMAMI (JP)
SEKIGUCHI TAKAHIRO (JP)
ENDO TAISUKE (JP)
ISHIYAMA AYUMI (JP)
NAITO TOMOHARU (JP)
HIGUCHI TAMAMI (JP)
SEKIGUCHI TAKAHIRO (JP)
ENDO TAISUKE (JP)
ISHIYAMA AYUMI (JP)
Application Number:
PCT/JP2018/048532
Publication Date:
July 04, 2019
Filing Date:
December 28, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
FUJIFILM CORP (JP)
FUJIFILM CORP (JP)
International Classes:
A61K31/7088; A61K9/127; A61K47/10; A61K47/18; A61K47/28; A61K47/32; A61K48/00; A61P13/10; A61P35/00; C12N15/00
Foreign References:
| JP2006111591A | 2006-04-27 | |||
| JP2008178358A | 2008-08-07 | |||
| JP2016023147A | 2016-02-08 |
Other References:
"Development of innovative drug for bladder cancer using ABH8-targeting synthetic nucleic acid", JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT, 23 May 2016 (2016-05-23), XP055624577, Retrieved from the Internet
KAWASAKI, RIKU ET AL.: "Protein transduction reagents", DRUG DELIVERY SYSTEM, vol. 31 - 2, 2016, pages 242 - 244, XP055624578
OHSHIO, IKUMI ET AL.: "ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 477, 2016, pages 413 - 418, XP029641753
SHIMADA, KEIJI ET AL.: "A Novel Human AlkB Homologue, ALKBH8 , Contributes to Human Bladder Cancer Progression", CANCER RESEARCH, vol. 69, 2009, pages 3157 - 3164, XP055624593
KAWASAKI, RIKU ET AL.: "Protein transduction reagents", DRUG DELIVERY SYSTEM, vol. 31 - 2, 2016, pages 242 - 244, XP055624578
OHSHIO, IKUMI ET AL.: "ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 477, 2016, pages 413 - 418, XP029641753
SHIMADA, KEIJI ET AL.: "A Novel Human AlkB Homologue, ALKBH8 , Contributes to Human Bladder Cancer Progression", CANCER RESEARCH, vol. 69, 2009, pages 3157 - 3164, XP055624593
Attorney, Agent or Firm:
SIKS & CO. (JP)
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