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Title:
PHARMACEUTICAL COMPOSITIONS OF ESTROGENIC AGENTS
Document Type and Number:
WIPO Patent Application WO2002003987
Kind Code:
A3
Abstract:
This invention comprises novel pharmaceutical carrier or excipient systems and oral pharmaceutical formulations comprising as an active ingredient raloxifene, amoxifen, droloxifene, arzoxifene, or CP 336156, or analogs thereof, or a compound of formulae (I) or (II), wherein Z is a moiety selected from the group of formulae (a, b or c), wherein: R1 is selected from H, OH or the C1-C12 esters alkyl ethers thereof, benzyloxy, or halogen; or C1-C4 halogenated ethers; R2, R3, R4, R5, and R6 are H, OH or C1-C12 esters or alkyl ethers thereof, halogens, or C1-C4 halogenated ethers, cyano, C1-C6 alkyl, or CF3, with the proviso that, when R1 is H, R2 is not OH; Y is the moiety:formulae (d), wherein R7 and R8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof; and excipients chosen from pharmaceutical fillers, glidants, lubricants, wetting agents and antioxidants.

Inventors:
BENJAMIN ERIC JOEL
DULIN WENDY ANN
SURYAWANSHI JIWAJI GULABRAO
Application Number:
PCT/US2001/020993
Publication Date:
July 11, 2002
Filing Date:
June 29, 2001
Export Citation:
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Assignee:
WYETH CORP (US)
International Classes:
A61K9/30; A61K9/48; A61K31/138; A61K31/40; A61K31/404; A61K31/4525; A61K31/4535; A61K31/55; A61K47/04; A61K47/10; A61K47/12; A61K47/20; A61K47/22; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61K9/20; (IPC1-7): A61K31/404; A61K9/20
Foreign References:
EP0670162A11995-09-06
EP0674903A11995-10-04
EP0729956A11996-09-04
FR2698788A11994-06-10
US5332727A1994-07-26
US5880137A1999-03-09
EP0802183A11997-10-22
EP0802184A11997-10-22
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