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Patent Searching and Data


Title:
PHARMACEUTICAL COMPOUND FOR TREATING COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2021/016987
Kind Code:
A1
Abstract:
A pharmaceutical compound TG1 (2, 3, 5, 4'-tetrahydroxy-trans-stilbene) and a new use for treating colorectal cancer thereofare provided. The pharmaceutical compound has the structure of formula I. Each variable in formula I and treating method are detailed in the specification.

Inventors:
LIAO SE-CHUN (CN)
CHEN SU-FEN (CN)
Application Number:
PCT/CN2019/098868
Publication Date:
February 04, 2021
Filing Date:
August 01, 2019
Export Citation:
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Assignee:
EVEREST PHARM IND CO LTD (CN)
LIAO SE CHUN (CN)
International Classes:
C07C39/21; A61P35/00
Foreign References:
CN110790639A2020-02-14
Other References:
MASAFUMI TAMURA, YUHEI KOSHIBE, KIHO KAJI, JUN-YA UEDA, YOSHIAKI SHIRATAKI: "Attempt to Synthesize 2,3,5,4′-Tetrahydroxystilbene Derived from 2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside (THSG)", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 63, no. 2, 31 December 2015 (2015-12-31), pages 122 - 125, XP055776872, ISSN: 0009-2363, DOI: 10.1248/cpb.c14-00626
RYU GEONSEEK, JU JEUNG HOON, PARK YONG JU, RYU SHI YONG, CHOI BYOUNG WOOK, LEE BONG HO: "The Radical Scavenging Effects of Stilbene Glucosides from Polygonum multiflorum", ARCHIVES OF PHARMACAL RESEARCH, vol. 25, no. 5, 31 December 2002 (2002-12-31), pages 636 - 639, XP055776874, ISSN: 0253-6269, DOI: 10.1007/BF02976935
HAN YONG NAM; RYU SHI YONG; HAN BYUNG HOON: "Antioxidant Activity of Resveratroi Closely Correlates with Its Monoamine oxidase-A Inhibitory Activity", ARCHIVES OF PHARMACAL RESEARCH, vol. 13, no. 2, 1 January 1990 (1990-01-01), pages 132 - 135, XP008118896, ISSN: 0253-6269
LIN CHIEN-LIANG, JENG JIIANG-HUEI, WU CHIH-CHUNG, HSIEH SHU-LING, HUANG GUAN-CHENG, LEUNG WAN, LEE CHINING-TING, CHEN CHUNG-YI, LE: "Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O- β -D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats", BIOMED RESEARCH INTERNATIONAL, vol. 2017, 3634915, 7 November 2017 (2017-11-07), pages 1 - 8, XP055776877, ISSN: 2314-6133, DOI: 10.1155/2017/3634915
DU YUANYUAN , JING CHANGWEN , WU JIANZHONG , MA RONG , JI FENGFENG: "Research progress of resveratrol on the treatment of colorectal cancer", CHINESE JOURNAL OF SURGICAL ONCOLOGY, vol. 11, no. 1, 20 February 2019 (2019-02-20), pages 65 - 69, XP055776882, ISSN: 1674-4136, DOI: 10.3969/j.issn.1674-4136.2019.01.015
KIMURA YOSHIYUKI, SUMIYOSHI MAHO, BABA KIMIYE: "Antitumor activities of synthetic and natural stilbenes through antiangiogenic action", CANCER SCIENCE, vol. 99, no. 10, 23 October 2008 (2008-10-23), pages 2083 - 2096, XP055776884, ISSN: 1347-9032, DOI: 10.1111/j.1349-7006.2008.00948.x
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (CN)
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