PHARMACEUTICAL TITANIUM DIOXIDE COMPOSITE MATERIAL OF WHICH PHARMACOLOGICAL EFFECT CAN BE ELIMINATED BY LIGHT IRRADIATION

WIPO Patent Application WO/2007/018147

A1

Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner. After the composite material is administered to a living body, a site on the living body where the pharmacological effect of the therapeutic compound is not needed to be developed can be irradiated with light to induce the light excitation of titanium dioxide at the site, thereby decomposing the therapeutic compound to reduce any adverse side effect of the therapeutic compound.

SONEZAKI SHUJI (JP)
KANEHIRA KOKI (JP)
OGAMI YUMI (JP)
BANZAI TOSHIAKI (JP)
KUBOTA YOSHINOBU (JP)

PCT/JP2006/315499

February 15, 2007

August 04, 2006

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TOTO LTD (JP)
SONEZAKI SHUJI (JP)
KANEHIRA KOKI (JP)
OGAMI YUMI (JP)
BANZAI TOSHIAKI (JP)
KUBOTA YOSHINOBU (JP)

A61K47/48; A61K9/10; A61K31/704; A61K38/00; A61K47/02; A61K47/32; A61P35/00

WO2004087577A1	2004-10-14
WO2003033143A1	2003-04-24
WO2003033145A1	2003-04-24

YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)

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