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Title:
PHARMACEUTICAL FOR TREATING FATTY LIVER DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/235508
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition for treating and/or preventing fatty liver diseases, in particular, nonalcoholic fatty liver diseases, said pharmaceutical composition having excellent ACC2-selective inhibitory action without accompanying side effects such as an increase in plasma triglycerides or a decrease in platelet concentration.　This pharmaceutical composition for treating and/or preventing fatty liver diseases comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof [in formula (I): R1 represents a haloalkyl or a nonaromatic carbocyclic group; R2 represents a hydrogen atom or a halogen; R3 represents a halogen; ring A is a group represented by formula (II); -L1- represents -O-(CH2)-, -(CH2)2-, etc.; R4 represents an alkyl or a haloalkyl; and R5 represents an alkylcarbonyl or carbamoyl].

Inventors:
YUKIOKA HIDEO (JP)
SHIMAZAKI ATSUYUKI (JP)
HAMADA TADATERU (JP)
Application Number:
PCT/JP2021/019088
Publication Date:
November 25, 2021
Filing Date:
May 20, 2021
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
International Classes:
A61K31/4184; A61K31/53; A61K31/573; A61K38/26; A61P1/16; A61P3/06; A61P3/10; A61P35/00; A61P43/00; C07D235/26; C07D405/12; C07J9/00
Domestic Patent References:
WO2016159082A12016-10-06
WO2019006324A12019-01-03
WO2015056782A12015-04-23
WO2013071169A12013-05-16
WO2016112305A12016-07-14
WO2011058474A12011-05-19
WO2015056782A12015-04-23
WO2016159082A12016-10-06
Foreign References:
JP2004523225A2004-08-05
JP2013542218A2013-11-21
JP2018501276A2018-01-18
US20140187633A12014-07-03
Other References:
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987, article "Labeled Compounds (Part A"
"Design of Prodrugs", 1985, ELSEVIER
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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