Title:
PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2018/152436
Kind Code:
A8
Abstract:
The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II) - (XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.
Inventors:
HUIGENS ROBERT WILLIAM (US)
GARRISON AARON (US)
ABOUELHASSAN YASMEEN (US)
YANG HONGFEN (US)
BURCH GENA (US)
GARRISON AARON (US)
ABOUELHASSAN YASMEEN (US)
YANG HONGFEN (US)
BURCH GENA (US)
Application Number:
PCT/US2018/018538
Publication Date:
September 12, 2019
Filing Date:
February 17, 2018
Export Citation:
Assignee:
UNIV FLORIDA (US)
International Classes:
C07D279/20
Attorney, Agent or Firm:
ZHANG, Wei (US)
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