Title:
PHENOL DERIVATIVE AND APPLICATION THEREOF IN MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO/2022/161312
Kind Code:
A1
Abstract:
Provided is a GABAA receptor agonist phenol derivative that has a novel structure and better efficacy, can effectively reduce side effects, and is safer for clinical use. Specifically disclosed are a compound as represented by the following formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and an application of the compound or composition of the present invention in the central nervous field, thereby providing more and better choices for medicaments for inducing and/or maintaining anesthesia in animal or human bodies, facilitating sedation and hypnosis, and treating and/or preventing anxiety, nausea, vomiting, migraine, convulsion, epilepsy, neurodegenerative diseases, and central nervous system-related diseases.
Inventors:
LIU JUNHUA (CN)
LIANG XUEPING (CN)
JIANG HAIGANG (CN)
WANG HENGXIN (CN)
DENG LILI (CN)
SONG ZHILIN (CN)
LIANG XUEPING (CN)
JIANG HAIGANG (CN)
WANG HENGXIN (CN)
DENG LILI (CN)
SONG ZHILIN (CN)
Application Number:
PCT/CN2022/073472
Publication Date:
August 04, 2022
Filing Date:
January 24, 2022
Export Citation:
Assignee:
HINYE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C39/04; A61K31/05; A61K31/095; A61K31/10; A61K31/222; A61P23/00; A61P25/00; C07C39/17
Domestic Patent References:
| WO2003026632A2 | 2003-04-03 |
Foreign References:
| CN105384608A | 2016-03-09 | |||
| CN112245426A | 2021-01-22 | |||
| US20050032753A1 | 2005-02-10 | |||
| CN104507899A | 2015-04-08 | |||
| CN104507898A | 2015-04-08 |
Other References:
JAMES, ROGER ET AL.: "Synthesis, Biological Evaluation, and Preliminary Structure-Activity Considerations of a Series of Alkylphenols as Intravenous Anesthetic Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 12, 31 December 1980 (1980-12-31), XP002489327, DOI: 10.1021/jm00186a013
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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