Title:
PHENYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, USE THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2021/031788
Kind Code:
A1
Abstract:
Disclosed are an immune checkpoint inhibitor capable of blocking a PD-1/PD-L1 signaling pathway, a phenyl-substituted five-membered heterocyclic compound or a pharmaceutically acceptable salt, racemate, optical isomer or solvent compound thereof, a preparation method therefor, use thereof, and a pharmaceutical composition comprising same. Such compound is represented by formula I below.
Inventors:
JIANG SHENG (CN)
HAO HAIPING (CN)
WANG TIANYU (CN)
WANG MINMIN (CN)
ZHANG WANHENG (CN)
NI YONG (CN)
QIU YATAO (CN)
WU XIAOXING (CN)
HAO HAIPING (CN)
WANG TIANYU (CN)
WANG MINMIN (CN)
ZHANG WANHENG (CN)
NI YONG (CN)
QIU YATAO (CN)
WU XIAOXING (CN)
Application Number:
PCT/CN2020/103850
Publication Date:
February 25, 2021
Filing Date:
July 23, 2020
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D271/113; A61K31/4196; A61K31/4245; A61K31/433; A61K31/4439; A61K31/444; A61K31/454; A61P35/00; C07D249/14; C07D271/07; C07D285/135; C07D413/10; C07D413/12; C07D413/14; C07D417/12
Domestic Patent References:
| WO2019145729A1 | 2019-08-01 | |||
| WO2019164996A1 | 2019-08-29 |
Foreign References:
| TW201734003A | 2017-10-01 | |||
| TW201734003A | 2017-10-01 | |||
| JP2012180281A | 2012-09-20 | |||
| CN107573332A | 2018-01-12 |
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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