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Title:
PLADIENOLIDE COMPOUNDS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO/2019/199667
Kind Code:
A3
Abstract:
The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Inventors:
KEANEY GREGG F (US)
WANG JOHN (US)
GERARD BAUDOUIN (US)
ARAI KENZO (JP)
LIU XIANG (US)
ZHENG GUO ZHU (US)
KIRA KAZUNOBU (JP)
MARCAURELLE LISA A (US)
NEVALAINEN MARTA (US)
HAO MING-HONG (US)
O'SHEA MORGAN WELZEL (US)
TIVITMAHAISOON PARCHAREE (US)
PRAJAPATI SUDEEP (US)
LUO TOUPING (US)
GEARHART NICHOLAS C (US)
LOWE JASON T (US)
KOTAKE YOSHIHIKO (JP)
NAGAO SATOSHI (JP)
KANADA SONOBE REGINA MIKIE (JP)
MIYANO MASAYUKI (JP)
MURAI NORIO (JP)
COOK ANDREW (US)
ELLERY SHELBY (US)
ENDO ATSUSHI (US)
PALACINO JAMES (US)
REYNOLDS DOMINIC (US)
Application Number:
PCT/US2019/026313
Publication Date:
November 21, 2019
Filing Date:
April 08, 2019
Export Citation:
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Assignee:
KEANEY GREGG F (US)
WANG JOHN (US)
GERARD BAUDOUIN (US)
ARAI KENZO (JP)
LIU XIANG (US)
ZHENG GUO ZHU (US)
KIRA KAZUNOBU (JP)
MARCAURELLE LISA A (US)
NEVALAINEN MARTA (US)
HAO MING HONG (US)
OSHEA MORGAN WELZEL (US)
TIVITMAHAISOON PARCHAREE (US)
PRAJAPATI SUDEEP (US)
LUO TOUPING (US)
GEARHART NICHOLAS C (US)
LOWE JASON T (US)
KOTAKE YOSHIHIKO (JP)
NAGAO SATOSHI (JP)
KANADA SONOBE REGINA MIKIE (JP)
MIYANO MASAYUKI (JP)
MURAI NORIO (JP)
COOK ANDREW (US)
ELLERY SHELBY (US)
ENDO ATSUSHI (US)
PALACINO JAMES (US)
REYNOLDS DOMINIC (US)
International Classes:
C07D313/00; A61K31/365; A61K31/4427; A61K31/497; A61P35/00; C07D407/12; C07D407/14
Domestic Patent References:
WO2015175594A12015-11-19
WO2017087667A12017-05-26
WO2013148324A12013-10-03
WO2007110704A22007-10-04
Foreign References:
US20140275010A12014-09-18
EP2168961A12010-03-31
EP1508570A12005-02-23
EP1712642A12006-10-18
Attorney, Agent or Firm:
MACALPINE, Jill K. (US)
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