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Title:
PLURAFLAVINS AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2001060832
Kind Code:
A3
Abstract:
The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is -CH2-O-(R7)m, R7 representing a sugar, or R2 is -COOH; R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4, R6, R8 and R10 independently of one another are H,C1-C6-alkyl, C2-C6-alkenyl, C2-C6-Alkynyl, -X2H, or -X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-Alkenyl, C2-C6-alkynyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; and its physiologically acceptable salts. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as anti-tumor agents.

Inventors:
VERTESY LASZLO
EHRLICH KLAUS
KNAUF MARTIN
WINK JOACHIM
BARBONE FRANCIS P
POWERS ELAINE A
CASHMAN ELIZABETH A
Application Number:
PCT/EP2001/001660
Publication Date:
January 31, 2002
Filing Date:
February 15, 2001
Export Citation:
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Assignee:
AVENTIS PHARMA GMBH (DE)
International Classes:
C12P19/58; A61K31/70; A61K31/7048; A61P1/00; A61P3/00; A61P11/00; A61P15/00; A61P31/00; A61P31/04; A61P35/00; A61P35/02; C07D311/78; C07H15/26; C07H17/04; C07H17/07; C12N1/20; C12P19/26; C12P19/60; (IPC1-7): C07H17/04; C12P19/60; C12P19/26; A61K31/70; A61P35/00; A61P35/02; A61P31/00
Domestic Patent References:
WO1990009435A11990-08-23
Foreign References:
Other References:
BRILL, GREGORY M. ET AL: "Altromycins E, F, G, H and I;additional novel components of the altromycin complex", J. ANTIBIOT. (1994), 47(10), 1160-4, XP002143378
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